Studying the effect of lipid chain length on the precipitation of a poorly water soluble drug from self‐emulsifying drug delivery system on dispersion into aqueous medium. (16th May 2013)

• Record Type: Journal Article
• Authors: Prasad, Dev; Chauhan, Harsh; Atef, Eman
• Is Part Of: Journal of pharmacy and pharmacology. Volume 65:Number 8(2013:Aug.)
• Page Start: 1134
• Page End: 1144
• Publication Date: 2013-05-16
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12077
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12077-sec-0001" sec-type="section"> <title>Objective</title> <p>The lipid excipients of the self‐emulsifying drug delivery systems (SEDDS) could play a role in interfering with the drug precipitation to maintain its supersaturation, a step with possible major significance on the SEDDS. Thus, the effect of lipid chain length on indomethacin precipitation rate from SEDDS upon dilution was studied.</p> </sec> <sec id="jphp12077-sec-0002" sec-type="section"> <title>Method</title> <p>Indomethacin SEDDS were prepared using medium and long chain lipids at 5% and 13% (w/w) drug load. Two medium chain lipids Lauroglycol and Capryol, and two long chain lipids Labrafil and castor oil, were studied. The 13% w/w SEDDS were evaluated for drug release, and the physicochemical properties of the precipitated drug were characterized by PXRD, DSC, IR and Raman.</p> </sec> <sec id="jphp12077-sec-0003" sec-type="section"> <title>Key findings</title> <p>The final optimized SEDDS consisted of Lauroglycol (lipid): Transcutol (co‐solvent): Labrasol (surfactant). No precipitate was observed with long chain lipids SEDDS, whereas medium chain lipids SEDDS showed precipitation within 30 min of drug release from 13% w/w formulations. Precipitation studies showed that the medium chain lipids resulted in a modified indomethacin form possibly an ester. The ester formation signifies the interaction between indomethacin and medium chain length lipids.</p> </sec> <sec id="jphp12077-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The study emphasizes the importance of lipids chain length of excipients in successful SEDDS formulations. The study provides insight into the underlying drug lipid interactions in SEDDS formulations.</p> </sec> </abstract>