Diagnostic yield of combined bronchoscopy and endobronchial ultrasonography, under LungPoint guidance for small peripheral pulmonary lesions. Issue 5 (21st June 2013)

• Record Type: Journal Article
• Authors: Tamiya, Motohiro; Okamoto, Norio; Sasada, Shinji; Shiroyama, Takayuki; Morishita, Naoko; Suzuki, Hidekazu; Yoshida, Emi; Hirashima, Tomonori; Kawahara, Kunimitu; Kawase, Ichiro
• Is Part Of: Respirology. Volume 18:Issue 5(2013)
• Page Start: 834
• Page End: 839
• Publication Date: 2013-06-21
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12095
• Languages: English
• ISSNs: 1323-7799

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="resp12095-sec-0001" sec-type="section"> <title>Background and objective</title> <p>The yield of biopsy performed during bronchoscopy is reduced if the lesion is smaller than 30 mm. We evaluated the performance of a new diagnostic technique combining endobronchial ultrasonography with a guide sheath (EBUS‐GS) and a virtual bronchoscopic navigation system, LungPoint (Broncus Technologies, Inc., Mountain View, CA, USA), for the diagnosis of small (≤30 mm) peripheral pulmonary lesions (PPL).</p> </sec> <sec id="resp12095-sec-0002" sec-type="section"> <title>Methods</title> <p>Between May 2011 and December 2011, we recruited 68 consecutive patients presenting with a PPL 30 mm or less in diameter determined by chest computed tomography. We used the LungPoint system before bronchoscopy to identify the bronchus into which the bronchoscope should be advanced. We used a thin bronchoscope. EBUS‐GS was performed using an endoscope ultrasonography system equipped with a 20‐MHz mechanical radial‐type probe. We used a guide sheath with an external diameter of 1.95 mm, thin forceps and brushing.</p> </sec> <sec id="resp12095-sec-0003" sec-type="section"> <title>Results</title> <p>The diagnostic yield of the 68 PPL was 77.9%; it was 83.7% and 68.0% for the malignant and benign lesions, respectively. Notably, three cases were diagnosed by transbronchial needle‐aspiration cytology alone. Univariate and multivariate analyses showed that the EBUS probe localization was the most significant contributor to successful diagnosis (diagnostic yield: within vs adjacent to the lesion = 92.1% vs 60.0%, respectively; <italic>P</italic> = 0.004 and <italic>P</italic> = 0.003, respectively).</p> </sec> <sec id="resp12095-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The combination of EBUS‐GS and LungPoint was useful for diagnosing small PPL.</p> </sec> </abstract>