Serum amyloid A is found on ApoB‐containing lipoproteins in obese humans with diabetes12. (20th June 2013)

• Record Type: Journal Article
• Authors: Jahangiri, Anisa; Wilson, Patricia G.; Hou, Tianfei; Brown, Aparna; King, Victoria L.; Tannock, Lisa R.
• Is Part Of: Obesity. Volume 21:Number 5(2013:May)
• Page Start: 993
• Page End: 996
• Publication Date: 2013-06-20
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20126
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Objective:</title> <p>In murine models of obesity/diabetes, there is an increase in plasma serum amyloid A (SAA) levels along with redistribution of SAA from high‐density lipoprotein (HDL) to apolipoprotein B (apoB)‐containing lipoprotein particles, namely, low‐density lipoprotein and very low‐density lipoprotein. The goal of this study was to determine if obesity is associated with similar SAA lipoprotein redistribution in humans.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Design and Methods:</title> <p>Three groups of obese individuals were recruited from a weight loss clinic: healthy obese (<italic>n</italic> = 14), metabolic syndrome (MetS) obese (<italic>n</italic> = 8), and obese with type 2 diabetes (<italic>n</italic> = 6). Plasma was separated into lipoprotein fractions by fast protein liquid chromatography, and SAA was measured in lipid fractions using enzyme‐linked immunosorbent assay and Western blotting.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>Only the obese diabetic group had SAA detectable in apoB‐containing lipoproteins, and SAA reverted back to HDL with active weight loss.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions:</title> <p>In human subjects, SAA is found in apoB‐containing lipoprotein particles only in obese subjects with type 2 diabetes, but not in healthy obese or obese subjects with MetS.</p> </sec> </abstract>