Genomic regions affecting backfat thickness and cannon bone circumference identified by genome‐wide association study in a Duroc pig population. (12th December 2012)

• Record Type: Journal Article
• Authors: Okumura, Naohiko; Matsumoto, Toshimi; Hayashi, Takeshi; Hirose, Kensuke; Fukawa, Kazuo; Itou, Tetsuya; Uenishi, Hirohide; Mikawa, Satoshi; Awata, Takashi
• Is Part Of: Animal genetics. Volume 44:Number 4(2013:Aug.)
• Page Start: 454
• Page End: 457
• Publication Date: 2012-12-12
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12018
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12018-abs-0001"> <title>Summary</title> <p>We performed a genome‐wide association study using the porcine 60K SNP array to detect QTL regions for nine traits in a three‐generational Duroc samples (<italic>n</italic> = 651), viz. generations 1, 2 and 3 from a population selected over five generations using a closed nucleus breeding scheme. We applied a linear mixed model for association mapping to detect SNP effects, adjusting for fixed effects (sex and season) and random polygenic effects (reflecting genetic relatedness), and derived a likelihood ratio statistic for each SNP using the efficient mixed‐model association method. We detected a region on SSC6 for backfat thickness (BFT) and on SSC7 for cannon bone circumference (CANNON), with a genome‐wide significance of <italic>P </italic>&lt;<italic> </italic>0.01 after Bonferroni correction. These regions had been detected previously in other pig populations. Six genes are located in the BFT‐associated region, while the CANNON‐associated region includes 66 genes. In the future, significantly associated SNPs, derived by sequencing the coding regions of the six genes in the BFT region, can be used in marker‐assisted selection of BFT, whereas haplotypes constructed from the SSC7 region with strong LD can be used to select for the CANNON trait in our resource family.</p> </abstract>