Incidence of cholinesterase inhibitor therapy initiation among hospitalized patients. Issue 6 (22nd March 2013)

• Record Type: Journal Article
• Authors: Swan, Joshua T.; Wagle, Kamal C.; Thompson‐Moore, Nathaniel; Taffet, George E.
• Is Part Of: Journal of hospital medicine. Volume 8:Issue 6(2013)
• Page Start: 304
• Page End: 308
• Publication Date: 2013-03-22
• Subjects: Hospital care -- Periodicals; Clinical medicine -- Periodicals; 610
• DOI: 10.1002/jhm.2030
• Languages: English
• ISSNs: 1553-5592

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jhm2030-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Initiation of cholinesterase inhibitor (ChEI) therapy for delirium during hospitalization is ineffective and may be associated with increased morbidity and mortality.</p> </sec> <sec id="jhm2030-sec-0002" sec-type="section"> <title>OBJECTIVE</title> <p>To describe the incidence of initiating ChEI therapy during hospitalization.</p> </sec> <sec id="jhm2030-sec-0003" sec-type="section"> <title>DESIGN</title> <p>A retrospective cross‐sectional study.</p> </sec> <sec id="jhm2030-sec-0004" sec-type="section"> <title>SETTING</title> <p>A tertiary‐care academic medical center.</p> </sec> <sec id="jhm2030-sec-0005" sec-type="section"> <title>PATIENTS</title> <p>Inpatient admissions from September 2010 through March 2011 with ChEI administration.</p> </sec> <sec id="jhm2030-sec-0006" sec-type="section"> <title>INTERVENTION</title> <p>None.</p> </sec> <sec id="jhm2030-sec-0007" sec-type="section"> <title>MEASUREMENTS</title> <p>Incidence of ChEI exposure, initiation of ChEI therapy, initiation of antipsychotics and benzodiazepines, infection, in‐hospital mortality, and hospital length of stay.</p> </sec> <sec id="jhm2030-sec-0008" sec-type="section"> <title>RESULTS</title> <p>The incidence of adult admissions with ChEI exposure and ChEI initiation was 23.2 (95% confidence interval: 21.2–25.4) and 2 (95% confidence interval 1.5‐2.8) per 1000 admissions, respectively. Of 476 admissions receiving ChEI, 9% (n = 42) initiated therapy during the hospital stay and 91% (n = 434) continued on previously started therapy. Patients initiated on ChEI therapy frequently had infection (20 of 42) and were commonly initiated on antipsychotics (14 of 42) and benzodiazepines (13 of 42). Patients were hospitalized for a median of 2 days (interquartile range, 1–4) before initiation of ChEI and were exposed to therapy for a median of 3 days (interquartile range, 2–6). Of the 41 patients discharged from the hospital, 90% (n = 37) had orders to continue the ChEI postdischarge.</p> </sec> <sec id="jhm2030-sec-0009" sec-type="section"> <title>CONCLUSIONS</title> <p>Despite a lack of evidence to support the practice, 9% of patients who received ChEI therapy were initiated during the inpatient setting. These patients were not routinely screened for delirium and frequently received treatments associated with delirium. <italic>Journal of Hospital Medicine</italic> 2013;8:304–308. © 2013 Society of Hospital Medicine.</p> </sec> </abstract>