Genome‐wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. (25th December 2012)

• Record Type: Journal Article
• Authors: Orr, N.; Hill, E. W.; Gu, J.; Govindarajan, P.; Conroy, J.; van, E. M.; Ducro, B. J.; van, J. A. M; Knaap, J. H.; van, P. R.; MacHugh, D. E.; Ennis, S.; Brama, P. A. J.
• Is Part Of: Animal genetics. Volume 44:Number 4(2013:Aug.)
• Page Start: 408
• Page End: 412
• Publication Date: 2012-12-25
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12016
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12016-abs-0001"> <title>Summary</title> <p>Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome‐wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2‐808543; <italic>P </italic>=<italic> </italic>5.03 × 10⁻⁷) and chromosome 10 (BIEC2‐121323; <italic>P </italic>=<italic> </italic>2.62 × 10⁻⁷).</p> </abstract>