Metabolic syndrome and the risk for recurrent pre‐eclampsia: a retrospective cohort study. Issue 8 (6th March 2013)

• Record Type: Journal Article
• Authors: Stekkinger, E; Scholten, RR; van der, MJ; van, APJ; Janssen, MCH; Spaanderman, MEA
• Is Part Of: BJOG. Volume 120:Issue 8(2013:Aug.)
• Page Start: 979
• Page End: 986
• Publication Date: 2013-03-06
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.12189
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" xml:lang="en" id="bjo12189-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo12189-sec-0001" sec-type="section"> <title>Objective</title> <p>To compare the prevalence of recurrent pre‐eclampsia between women who have and do not have metabolic syndrome when non‐pregnant.</p> </sec> <sec id="bjo12189-sec-0002" sec-type="section"> <title>Design</title> <p>Retrospective cohort study.</p> </sec> <sec id="bjo12189-sec-0003" sec-type="section"> <title>Setting</title> <p>Three tertiary referral hospitals in the Netherlands.</p> </sec> <sec id="bjo12189-sec-0004" sec-type="section"> <title>Population</title> <p>Formerly pre‐eclamptic women.</p> </sec> <sec id="bjo12189-sec-0005" sec-type="section"> <title>Methods</title> <p>The presence or absence of metabolic syndrome was assessed in 480 women at least 6 months after their first pre‐eclamptic pregnancy using World Health Organization criteria. We compared the prevalence of recurrent pre‐eclampsia in the subsequent pregnancy, calculating odds ratios (OR), adjusted for confounders.</p> </sec> <sec id="bjo12189-sec-0006" sec-type="section"> <title>Main outcome measure</title> <p>Recurrence of pre‐eclampsia in the subsequent pregnancy.</p> </sec> <sec id="bjo12189-sec-0007" sec-type="section"> <title>Results</title> <p>Subsequent pregnancy outcome data were available for 197 women. Forty women had metabolic syndrome after previous pregnancy (20%). The prevalence of recurrent pre‐eclampsia was 18/40 (45%) in women with metabolic syndrome versus 27/157 (17%) in women without metabolic syndrome; OR 3.94 (95% confidence interval [CI] 1.86–8.33, adjusted OR 3.77 (95% CI 1.61–8.81). The risk of recurrent pre‐eclampsia increased with each extra component of the metabolic syndrome from 11.8% for absent components up to 43.9% for three or more (<italic>P</italic> for trend < 0.001).</p> </sec> <sec id="bjo12189-sec-0008" sec-type="section"> <title>Conclusions</title> <p>Interpregnancy metabolic syndrome predisposes to recurrent pre‐eclampsia.</p> </sec> </abstract>