Alterations in Adipokines in Feline Hepatic Lipidosis. (10th March 2013)

• Record Type: Journal Article
• Authors: Mazaki‐Tovi, M.; Abood, S.K.; Segev, G.; Schenck, P.A.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 2(2013:Mar./Apr.)
• Page Start: 242
• Page End: 249
• Publication Date: 2013-03-10
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12055
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12055-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12055-sec-0001" sec-type="section"> <title>Background</title> <p>Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid‐lowering and insulin‐sensitizing effects.</p> </sec> <sec id="jvim12055-sec-0002" sec-type="section"> <title>Hypothesis</title> <p>Serum concentrations of adiponectin and leptin are altered in feline HL.</p> </sec> <sec id="jvim12055-sec-0003" sec-type="section"> <title>Animals</title> <p>Client‐owned cats: 55 healthy and 45 with liver disease.</p> </sec> <sec id="jvim12055-sec-0004" sec-type="section"> <title>Methods</title> <p>Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined.</p> </sec> <sec id="jvim12055-sec-0005" sec-type="section"> <title>Results</title> <p>Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 μg/mL), HL and concurrent disease (4.4 μg/mL), or other liver disease (6.1 μg/mL), as compared with healthy cats (1.5 μg/mL; <italic>P </italic><<italic> </italic>.001, <italic>P </italic><<italic> </italic>.001, and <italic>P = </italic>.04, respectively). Mean serum concentration of leptin was higher in cats with HL (9.8 ng/mL) or HL and concurrent disease (10.7 ng/mL) than healthy cats (4.9 ng/mL, <italic>P </italic><<italic> </italic>.001 and <italic>P </italic><<italic> </italic>.001, respectively). Cats with other liver disease had leptin concentration (4.9 ng/mL) similar to healthy cats. Concentrations of adiponectin were correlated with alanine aminotransferase activity (<italic>r </italic>=<italic> </italic>0.40, <italic>P </italic>=<italic> </italic>.0069), and concentrations of leptin were correlated with alkaline phosphatase activity (<italic>r </italic>=<italic> </italic>0.42, <italic>P </italic>=<italic> </italic>.0051) in cats with liver disease.</p> </sec> <sec id="jvim12055-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Adipokine concentrations are altered in feline HL. Increased concentrations of adiponectin are related to liver disease, whereas increased concentrations of leptin are specifically related to HL.</p> </sec> </abstract>