Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model. (11th October 2012)

• Record Type: Journal Article
• Authors: Petersen, Signe Beck; Nielsen, Flemming Seier; Ribel, Ulla; Sturis, Jeppe; Skyggebjerg, Ole
• Is Part Of: Journal of pharmacy and pharmacology. Volume 65:Number 2(2013:Feb.)
• Page Start: 230
• Page End: 235
• Publication Date: 2012-10-11
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/j.2042-7158.2012.01596.x
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp1596-sec-0001" sec-type="section"> <title>Objectives</title> <p>The aim of the study was to investigate the pharmacokinetic properties of insulin aspart (IAsp) in three different concentrations given as a continuous subcutaneous insulin infusion (CSII).</p> </sec> <sec id="jphp1596-sec-0002" sec-type="section"> <title>Methods</title> <p>A randomized cross‐over study was performed in pigs, where IAsp U200, U100 or U20 was given for 8 h with the same total dose. Six pigs were included and blood was sampled during the CSII and 3 h after.</p> </sec> <sec id="jphp1596-sec-0003" sec-type="section"> <title>Key findings</title> <p>The half‐life (t<sub>1/2</sub>) was 24.3 (range 17.3–41.3), 28.8 (range 19.6–54.3) and 23.6 (range 17.4–36.8) min for U200, U100 and U20, respectively. The area under the curve per dose (AUC/D) was determined to be 51.2 ± 19.5, 52.3 ± 12.5 and 51.6 ± 6.7 p<sc>m</sc> × min/kg for U200, U100 and U20, respectively. The steady state plasma concentration (C<sub>ss</sub>) was 57.5 ± 27.1, 54.3 ± 10.3 and 55.1 ± 8.0 p<sc>m</sc> (mean ± SD) for U200, U100 and U20, respectively. Time to steady state (T<sub>ss</sub>) was 110 ± 36, 98 ± 48 and 90 ± 27 min for U200, U100 and U20, respectively.</p> </sec> <sec id="jphp1596-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In conclusion, no significant difference was found in t<sub>1/2</sub>, AUC/D, C<sub>ss</sub> or T<sub>ss</sub> between the three IAsp concentrations when given at a basal rate in CSII.</p> </sec> </abstract>