Fibroblast Growth Factor 23 in Feline Chronic Kidney Disease. (11th February 2013)

• Record Type: Journal Article
• Authors: Geddes, R.F.; Finch, N.C.; Elliott, J.; Syme, H.M.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 2(2013:Mar./Apr.)
• Page Start: 234
• Page End: 241
• Publication Date: 2013-02-11
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12044
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12044-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12044-sec-0001" sec-type="section"> <title>Background</title> <p>Fibroblast growth factor 23 (FGF‐23) is a phosphaturic hormone involved in the pathogenesis of secondary renal hyperparathyroidism (SRHP) in humans. There are no published studies examining feline FGF‐23.</p> </sec> <sec id="jvim12044-sec-0002" sec-type="section"> <title>Objectives</title> <p>Validation of a method for FGF‐23 quantification in feline plasma and assessment of the associations among plasma FGF‐23, PTH, creatinine, and phosphate concentrations in cats with chronic kidney disease (CKD).</p> </sec> <sec id="jvim12044-sec-0003" sec-type="section"> <title>Animals</title> <p>One hundred nonazotemic and azotemic geriatric (>9 years) client‐owned cats.</p> </sec> <sec id="jvim12044-sec-0004" sec-type="section"> <title>Methods</title> <p> <italic>Retrospective cross‐sectional study</italic>: Cats were categorized into 4 groups: control group (plasma creatinine (Cr) ≤2.0 mg/dL), stage 2 (Cr 2.1–2.8 mg/dL), stage 3 (Cr 2.9–5.0 mg/dL), stage 4 (Cr >5.0 mg/dL). Stages 2 and 3 were further subdivided based on International Renal Interest Society targets for plasma phosphate concentration (PO<sub>4</sub>): stage 2a (PO<sub>4</sub> ≤4.5 mg/dL), stage 2b (PO<sub>4</sub> >4.5 mg/dL), stage 3a (PO<sub>4</sub> ≤5 mg/dL), stage 3b (PO<sub>4</sub> >5 mg/dL). Plasma FGF‐23 concentrations were measured by a human intact FGF‐23 ELISA. Descriptive statistics and linear regression were performed.</p> </sec> <sec id="jvim12044-sec-0005" sec-type="section"> <title>Results</title> <p>The ELISA demonstrated acceptable precision, reproducibility, and specificity. Plasma FGF‐23 concentrations increased with increasing plasma creatinine concentrations and were significantly different between all groups (<italic>P</italic> < .008). Plasma FGF‐23 concentrations were significantly higher in cats in stage 2b than stage 2a (<italic>P</italic> = .008) and in stage 3b than in stage 3a (<italic>P</italic> = .012). Phosphate, log creatinine, total calcium, log parathyroid hormone, and packed cell volume were all independent predictors of FGF‐23.</p> </sec> <sec id="jvim12044-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>FGF‐23 concentrations increase with increasing stage of feline CKD and might be a marker or mediator of feline SRHP.</p> </sec> </abstract>