A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice. Issue 6 (25th April 2013)

• Record Type: Journal Article
• Authors: Deng, Kai; Zhou, Li Ya; Lin, San Ren; Li, Yuan; Chen, Mo; Geng, Qiu Ming; Li, Yu Wen
• Is Part Of: Journal of digestive diseases. Volume 14:Issue 6(2013:Jun.)
• Page Start: 299
• Page End: 304
• Publication Date: 2013-04-25
• Subjects: Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; 616.3
• DOI: 10.1111/1751-2980.12040
• Languages: English
• ISSNs: 1751-2972

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cdd12040-sec-0001" sec-type="section"> <title>Objective</title> <p>This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening.</p> </sec> <sec id="cdd12040-sec-0002" sec-type="section"> <title>Methods</title> <p>Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were divided into three groups: the normal mucosa or chronic non‐atrophic gastritis (NM‐CNAG) group (<italic>n</italic> = 35), advanced gastric cancer (AGC) group (<italic>n</italic> = 33) and EGC group (<italic>n</italic> = 33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (P<sub>1</sub>FI) was measured.</p> </sec> <sec id="cdd12040-sec-0003" sec-type="section"> <title>Results</title> <p>The mean fluorescence intensity of P<sub>1</sub>FI of gastric juice in AGC (92.1 ± 10.7) and EGC (90.8 ± 12.0) groups was significantly higher than that in the NM‐CNAG group (55.7 ± 7.5) (AGC <italic>vs</italic> NM‐CNAG, <italic>P</italic> = 0.006 and EGC <italic>vs</italic> NM‐CNAG, <italic>P</italic> = 0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [CI] 0.553–0.810, <italic>P</italic> = 0.010) and 0.655 (95% CI 0.522–0.787, <italic>P</italic> = 0.028). With the P<sub>1</sub>FI of ≥47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively.</p> </sec> <sec id="cdd12040-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The enhancement of P<sub>1</sub>FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.</p> </sec> </abstract>