Association study of STAT4 polymorphisms and type 1 diabetes in Northeastern Chinese Han population. Issue 3 (30th January 2013)

• Record Type: Journal Article
• Authors: Bi, C.; Li, B.; Cheng, Z.; Hu, Y.; Fang, Z.; Zhai, A.
• Is Part Of: Tissue antigens. Volume 81:Issue 3(2013)
• Page Start: 137
• Page End: 140
• Publication Date: 2013-01-30
• Subjects: Antigens -- Periodicals; Immunological tolerance -- Periodicals; Immunogenetics -- Periodicals; 571.9645
• DOI: 10.1111/tan.12057
• Languages: English
• ISSNs: 0001-2815

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Type 1 diabetes (T1D) is an organ‐specific, T‐cell‐mediated disease resulting from the selective destruction of pancreatic β cells. The signal transducer and activator of transcription 4 (<italic>STAT4</italic>) gene is one of the most interesting genes for the pathogenesis of autoimmune diseases, including T1D. In this study, a case–control study was conducted in a Han population in northeastern China comparing the genotypes of T1D patients to healthy controls for the presence of two single‐nucleotide polymorphisms (SNPs) in the <italic>STAT4</italic> gene. The study population comprised of 410 T1D patients and 407 healthy individuals. Two SNPs (rs7574865 and rs3024866) of <italic>STAT4</italic> were genotyped with Multiplex SNaPShot method. Data were analyzed with <sc>spss</sc> 13.0 to determine if a statistical association existed between these genotypes and T1D. One of the two SNPs (rs7574865) was strongly associated with T1D in Northeastern Chinese population compared to healthy controls (<italic>P</italic> <italic>&lt;</italic> 0.05), whereas the other tested SNP (rs3024866) demonstrated no significant relationship. In conclusion, the <italic>STAT4</italic> gene may play an important role in facilitating susceptibility to T1D in this Han Chinese population.</p> </abstract>