Recognition of a Caucasoid HLA‐B locus allele, B*44:55, in a Taiwanese/Chinese bone marrow stem cell donor. (3rd August 2012)

• Record Type: Journal Article
• Authors: Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.
• Is Part Of: International journal of immunogenetics. Volume 40:Number 2(2013:Apr.)
• Page Start: 154
• Page End: 155
• Publication Date: 2012-08-03
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/j.1744-313X.2012.01146.x
• Languages: English
• ISSNs: 1744-3121

Abstract

<abstract abstract-type="main" id="iji1146-abs-0001"> <title>Summary</title> <p>We detected a Caucasoid HLA‐B allele, HLA‐B*44:55, in a potential Taiwanese/Chinese bone marrow hematopoietic stem cell donor during our routine HLA SBT (sequence‐based typing) practice. The sequence of B*44:55 varies with B*44:02:01:01 with one nucleotide in exon 2 at position 97 (T‐&gt;C), while it differs from B*44:03:01 with one nucleotide in exon 2 at position 97 (T‐&gt;C) and three nucleotides in exon 3 at residues 538–540 (CTG‐&gt;GAC). The nucleotide replacements caused one amino acid variation with B*44:02:01:01 at residue 9 (Y‐&gt;H) and two amino acid variations with B*44:03:01 at residue 9 (Y‐&gt;H) and residue 156 (L‐&gt;D). The formation of B*44:55 is probably the result of a nucleotide substitution involving B*44:02:01:01 at position 97 (T‐&gt;C). The Taiwanese/Chinese donor with B*44:55 claims having no kinship with Caucasian. Our speculations on the origin of the Taiwanese/Chinese B*44:55 will be presented.</p> </abstract>