The cytochrome P450 complement (CYPome) of Mycosphaerella graminicola. (25th January 2013)

• Record Type: Journal Article
• Authors: Newsome, Alun W.; Nelson, David; Corran, Andrew; Kelly, Steven L.; Kelly, Diane E.; Gilardi, Gianfranco
• Is Part Of: Biotechnology and applied biochemistry. Volume 60:Number 1(2013:Jan./Feb.)
• Page Start: 52
• Page End: 64
• Publication Date: 2013-01-25
• Subjects: Biotechnology -- Periodicals; Biochemical engineering -- Periodicals; Biochemistry -- Periodicals; Biochemistry -- Periodicals; Genetic Techniques -- Periodicals; Microbiological Techniques -- Periodicals; 660.6
• DOI: 10.1002/bab.1062
• Languages: English
• ISSNs: 0885-4513

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p> <italic>Mycosphaerella graminicola</italic> is a key fungal pathogen of wheat and a major target for azole fungicides, many of whose central mode of action is through inhibition of cytochrome P450 51 (lanosterol 14α‐demethylase) in the ergosterol biosynthetic pathway. The range of activities of other fungal CYPs is thought to be a reflection of the differences between different organisms and their range of secondary metabolic pathways as a response to their niche environments, for example, in the production of mycotoxins. The present study collates information from a range of databases, to classify the CYPs found in <italic>M. graminicola</italic> and assign them an internationally recognized nomenclature, which, when referenced to the recent publication of the JGI version 2.0 genome model, creates a current, robust model for the CYP complement (CYPome) of <italic>M. graminicola</italic>. These CYPome data, which examined 82 CYPs and one pseudo‐gene, may be utilized not only to further characterize and describe the physiology of the organism but also to enhance our understanding of CYP function and diversity.</p> </abstract>