Fibroblast Growth Factor 23 (FGF‐23) Concentrations in Cats with Early Nonazotemic Chronic Kidney Disease (CKD) and in Healthy Geriatric Cats. (30th January 2013)

• Record Type: Journal Article
• Authors: Finch, N.C.; Geddes, R.F.; Syme, H.M.; Elliott, J.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 2(2013:Mar./Apr.)
• Page Start: 227
• Page End: 233
• Publication Date: 2013-01-30
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12036
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12036-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12036-sec-0001" sec-type="section"> <title>Background</title> <p>Fibroblast growth factor (FGF‐23) has an important role in phosphate regulation. Its clinical relevance in cats with CKD has not been explored previously.</p> </sec> <sec id="jvim12036-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>The study objectives were (1) to determine whether FGF‐23 concentrations are increased in nonazotemic cats, cats which developed azotemia within 12 months of screening compared with cats that remained non‐azotemic, and (2) to evaluate the relationships between FGF‐23 and PTH and FGF‐23 and glomerular filtration rate (GFR).</p> </sec> <sec id="jvim12036-sec-0003" sec-type="section"> <title>Animals</title> <p>Sixty‐two healthy client‐owned geriatric cats, 14 of which developed azotemia during the 12‐month follow‐up period.</p> </sec> <sec id="jvim12036-sec-0004" sec-type="section"> <title>Methods</title> <p>Healthy nonazotemic cats were recruited prospectively into the study and followed for 12 months. At the study end‐point, cats were categorized into 3 groups according to plasma creatinine concentration. PTH, FGF‐23, and additional biochemical variables were evaluated at baseline and after 12 months. GFR was measured by a corrected slope‐intercept iohexol clearance method.</p> </sec> <sec id="jvim12036-sec-0005" sec-type="section"> <title>Results</title> <p>FGF‐23 concentrations at baseline were found to be significantly increased in cats that developed azotemia (<italic>P</italic> = .001) compared with cats that did not develop azotemia. A significant positive relationship was identified between FGF‐23 and PTH, whereas the relationship between FGF‐23 and GFR was negative.</p> </sec> <sec id="jvim12036-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>FGF‐23 concentrations predicted development of azotemia in geriatric cats. Positive relationships between FGF‐23 and PTH suggest an association between FGF‐23 and renal secondary hyperparathyroidism.</p> </sec> </abstract>