18F‐FDG‐PET/CT predicts early tumor recurrence in living donor liver transplantation for hepatocellular carcinoma. (25th October 2012)

• Record Type: Journal Article
• Authors: Lee, Seung Duk; Kim, Seong Hoon; Kim, Young‐Kyu; Kim, Chulhan; Kim, Seok‐Ki; Han, Sung‐Sik; Park, Sang‐Jae
• Is Part Of: Transplant international. Volume 26:Number 1(2013:Jan.)
• Page Start: 50
• Page End: 60
• Publication Date: 2012-10-25
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/j.1432-2277.2012.01572.x
• Languages: English
• ISSNs: 0934-0874

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Summary</title> <p>The prognosis including <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F‐FDG‐PET/CT) for the early recurrence for hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT) was not well established. Consecutive patients who underwent <sup>18</sup>F‐FDG‐PET/CT and subsequent LDLT for HCC from March 2005 to June 2011 were enrolled. The 191 patients with a median follow‐up of 26.1 months were evaluated. There were 20 patients (10.5%) with early recurrence (≤6 months), 18 patients (9.4%) with late recurrence (>6 months), and 153 patients (80.1%) with no recurrence. Fifty‐five patients (28.8%) displayed increased PET/CT tumor uptake. Three‐year overall and disease‐free survival for PET/CT‐positive patients were 65.5% and 57.1%, respectively, while PET/CT‐negative patients showed respective values of 89.8% and 86.8% (<italic>P </italic>=<italic> </italic>0.001 vs. <italic>P </italic><<italic> </italic>0.001). Tumor variables associated with PET/CT‐positive finding were preoperative AFP level, Milan, UCSF criteria, maximum tumor size, total tumor size, differentiation, vascular invasion, and serosal invasion. PET/CT‐positive status was identified as an independent prognostic factor for disease‐free survival influencing early recurrence in multivariable analysis (HR 3.945, 95% CI 1.196–13.016, <italic>P </italic>=<italic> </italic>0.024). <sup>18</sup>F‐FDG‐PET/CT is an independent and significant predictor of early tumor recurrence in LDLT for HCC.</p> </abstract>