Systemic Associations of Dynamic Retinal Vessel Analysis: A Review of Current Literature. (10th April 2013)

• Record Type: Journal Article
• Authors: Lim, Michelle; Sasongko, Muhammad B.; Ikram, Mohammad K.; Lamoureux, Ecosse; Wang, Jie Jin; Wong, Tien Yin; Cheung, Carol Y.
• Is Part Of: Microcirculation. Volume 20:Number 3(2013:Apr.)
• Page Start: 257
• Page End: 268
• Publication Date: 2013-04-10
• Subjects: Biological transport -- Periodicals; Microcirculation -- Physiology -- Periodicals; 612.135
• DOI: 10.1111/micc.12026
• Languages: English
• ISSNs: 1073-9688

Abstract

<abstract abstract-type="main" xml:lang="en" id="micc12026-abs-0001"> <title>Abstract</title> <p>Endothelial dysfunction is a key pathogenic mechanism of CVD. The retinal microvascular network offers a unique, non‐invasive window to study endothelial function. Recently, dynamic measurement of retinal vessel caliber using flicker light stimulation has been used to evaluate potential endothelial dysfunction and other mechanisms in CVD. A variety of studies now indicate that retinal vasodilation during flicker light simulation is reduced in diabetes, hypertension, hyperlipidemia and obesity, and may be influenced by age and race/ethnicity. These data suggest that flicker light‐induced retinal vasodilation may be a unique and non‐invasive measure of endothelial dysfunction. This review focuses recent studies on systemic associations of flicker light‐induced retinal vasodilation, and discusses the potential for future research in this area.</p> </abstract>