Transcatheter arterial embolization followed by octreotide and celecoxib synergistically prolongs survival of rabbits with hepatic VX2 allografts. Issue 1 (21st December 2012)

• Record Type: Journal Article
• Authors: Tong, Huan; Li, Xiao; Zhang, Chun Le; Gao, Jin Hang; Wen, Shi Lei; Huang, Zhi Yin; Wen, Fu Qiang; Fu, Ping; Tang, Cheng Wei
• Is Part Of: Journal of digestive diseases. Volume 14:Issue 1(2013:Jan.)
• Page Start: 29
• Page End: 37
• Publication Date: 2012-12-21
• Subjects: Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; 616.3
• DOI: 10.1111/1751-2980.12001
• Languages: English
• ISSNs: 1751-2972

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cdd12001-sec-0001" sec-type="section"> <title>Objective</title> <p>To validate the efficacy of an innovative multimodality therapy with transcatheter arterial embolization (TAE) plus octreotide and celecoxib in reducing neoangiogenesis and prolonging the survival of rabbits with hepatocellular carcinoma.</p> </sec> <sec id="cdd12001-sec-0002" sec-type="section"> <title>Methods</title> <p>Rabbits with hepatic VX2 allografts were divided into four groups: control group, TAE group, octreotide + celecoxib (O + C) group and the multimodality therapy (TAE + O + C) group. Survival of the rabbits was analyzed using the Kaplan–Meier method and the expression of CD31 in tumor tissues was detected by immunohistochemistry.</p> </sec> <sec id="cdd12001-sec-0003" sec-type="section"> <title>Results</title> <p>Rabbits in the TAE + O + C group lived nearly 20 days longer than those in the control group. The survival rate of the TAE + O + C group was 50% at day 80 and was the highest among the four groups (<italic>P</italic> < 0.05). No VX2 allograft‐bearing rabbits in the control group lived longer than 60 days. Compared with the control group, the survival time of the other two intervention groups were not prolonged significantly (<italic>P</italic> > 0.05). The CD31 expression induced by TAE was reduced significantly in TAE + O + C group (<italic>P</italic> < 0.05). Less metastasis was detected in TAE + O + C group.</p> </sec> <sec id="cdd12001-sec-0004" sec-type="section"> <title>Conclusion</title> <p>TAE followed by the long‐term administration of octreotide and celecoxib can synergistically prolong the survival of rabbits with hepatic VX2 allografts by inhibiting potential neoangiogenesis, tumor growth and metastasis.</p> </sec> </abstract>