Nonalcoholic fatty liver in nondiabetic patients with acute coronary syndromes. (11th March 2013)

• Record Type: Journal Article
• Authors: Boddi, Maria; Tarquini, Roberto; Chiostri, Marco; Marra, Fabio; Valente, Serafina; Giglioli, Cristina; Gensini, Gian F.; Abbate, Rosanna
• Is Part Of: European journal of clinical investigation. Volume 43:Number 5(2013:May)
• Page Start: 429
• Page End: 438
• Publication Date: 2013-03-11
• Subjects: Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12065
• Languages: English
• ISSNs: 0014-2972

Abstract

<abstract abstract-type="main" xml:lang="en" id="eci12065-abs-0001"> <title>Abstract</title> <sec id="eci12065-sec-0001" sec-type="section"> <title>Background</title> <p>Growing evidence was collected that non‐alcoholic liver fatty disease (NAFLD) is a risk factor for coronary atherosclerosis in terms of angiographic appearance, but its involvement in acute coronary syndromes is still debated. We investigated the prevalence and severity of NAFLD in non‐diabetic patients admitted for ST‐segment elevation myocardial infarction (STEMI) and its association with multi‐vessel coronary artery disease (CAD).</p> </sec> <sec id="eci12065-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>Ninety‐five consecutive non‐diabetic patients admitted to cardiac ICU for STEMI were studied by ultrasound within 72 h from admission. NAFLD was graded according to a semi‐quantitative severity score as mild (score < 3) or moderate‐severe (> 3 score). Prevalence of cardiovascular (CV) risk factors, atherosclerotic burden markers and metabolic syndrome (MS) was investigated.</p> </sec> <sec id="eci12065-sec-0003" sec-type="section"> <title>Results</title> <p>The overall prevalence of NAFLD was 87%. Forty‐eight patients showed moderate‐severe NAFLD (SFLD). Thirty‐five patients showed mild NAFLD (MLFD group) and 12 patients had no NAFLD. Patients with SFLD were younger and showed higher prevalence of multi‐vessel CAD (i.e. > 2) than patients with mild MFLD (<italic>P</italic> < 0·01). Total cholesterol, triglycerides, body mass index and waist circumference were higher and HDL lower in SFLD than MFLD patients. About 50% of all NAFLD patients did not have MS. MS prevalence was higher in SFLD than MLFD patients (<italic>P</italic> < 0·05) and among MS components, waist circumference and triglyceride levels showed the strongest association with SFLD (<italic>P</italic> < 0·05). At logistic regression analysis, SFLD was independently associated with a three‐fold risk of multi‐vessel CAD.</p> </sec> <sec id="eci12065-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In non‐diabetic patients admitted for STEMI NAFLD prevalence was very high. Severe NAFLD independently increased the risk for multi‐vessel CAD associated to CV events.</p> </sec> </abstract>