The impact of predisposing factors on long‐term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry. Issue 6 (9th February 2013)

• Record Type: Journal Article
• Authors: Kuwashiro, T.; Sugimori, H.; Ago, T.; Kuroda, J.; Kamouchi, M.; Kitazono, T.
• Is Part Of: European journal of neurology. Volume 20:Issue 6(2013:Jun.)
• Page Start: 921
• Page End: 927
• Publication Date: 2013-02-09
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12100
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12100-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12100-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Although stroke patients with diabetes mellitus have a poor prognosis, the prognostic factors of patients with diabetes mellitus have not been adequately studied. The aim of this study was to determine the predisposing factors for outcome 1 year after stroke in diabetic patients.</p> </sec> <sec id="ene12100-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients' characteristics, findings on admission and outcome 1 year after first ischaemic stroke were prospectively investigated in 452 consecutive patients with diabetes mellitus (305 males, 147 females; 69 ± 10 years old). A poor outcome was defined as a modified Rankin Scale (mRS) score ≥ 2, 1 year after stroke onset.</p> </sec> <sec id="ene12100-sec-0003" sec-type="section"> <title>Results</title> <p>There were 286 patients with a good outcome (mRS score ≤ 1) and 166 with a poor outcome (mRS score ≥ 2). On multivariate logistic regression analysis, age [odds ratio (OR) 1.06, 95% confidence interval (CI) 1.03–1.10, <italic>P </italic>< 0.001, per 1‐year increase], National Institutes of Health Stroke Scale (NIHSS) score on admission (OR 1.21, 95% CI 1.11–1.32, <italic>P </italic>< 0.001, per 1‐point increase), diabetic nephropathy (OR 1.93, 95% CI 1.02–3.65, <italic>P </italic>= 0.044) and hemoglobin A1c (HbA1c; OR 1.27, 95% CI 1.07–1.51, <italic>P </italic>= 0.007, per 1% increase) were independently related to poor outcome (mRS score ≥ 2) 1 year after the onset of the first stroke in diabetic patients.</p> </sec> <sec id="ene12100-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In stroke patients with diabetes mellitus, age, NIHSS score on admission, diabetic nephropathy and HbA1c were independently associated with a poor outcome 1 year after the first ischaemic stroke.</p> </sec> </abstract>