Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation. (5th January 2012)

• Record Type: Journal Article
• Authors: Wu, Y.; Jia, L.‐L.; Zheng, Y.‐N.; Xu, X.‐G.; Luo, Y.‐J.; Wang, B.; Chen, J.Z.S.; Gao, X.‐H.; Chen, H.‐D.; Matsui, M.; Li, Y.‐H.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 27:Number 3(2013:Mar.)
• Page Start: 345
• Page End: 350
• Publication Date: 2012-01-05
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/j.1468-3083.2011.04414.x
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p> <bold>Background </bold> Ultraviolet (UV) exposure results in the production reactive oxygen species. Resveratrol has attracted considerable attentions owing to its natural abundance and multiple biological effects.</p> <p> <bold>Objective </bold> To investigate the protective effects of resveratrate against damage to human skin induced by repetitive solar simulator ultraviolet radiation (ssUVR).</p> <p> <bold>Materials and methods </bold> Fifteen healthy volunteers were enrolled, and six sites on the non‐exposed dorsal skin of each volunteer were marked for study. Sites 1–4 were exposed to ssUVR at a dosage of 1.5 minimal erythema dose for consecutive 4 days. Immediately after each exposure, one test material (resveratrate + antioxidant, antioxidant, resveratrate, vehicle) was applied to one of the four sites. Site 5 and site 6 were marked as positive control site (UVR only) and baseline control site (no treatment, no UVR). <italic>L</italic>*<italic>a</italic>*<italic>b</italic> values were assessed preprocedure and postprocedure. Skin biopsies were taken 24 h after the last irradiation. The specimens were stained to determine the number of sunburn cells and melanin content melanin.</p> <p> <bold>Results </bold> On resveratrate treated sites, erythema was barely seen with only slight decrease of <italic>L</italic> value and insignificant increase of *<italic>a</italic> value. Furthermore, resveratrate significantly inhibited sunburn cell formation, and decreased Fontana‐Masson staining in skin samples.</p> <p> <bold>Conclusions </bold> Resveratrate exerts protective effects against repetitive ssUVR‐induced sunburn and suntan.</p> </abstract>