A review of expression profiling of circulating microRNAs in men with prostate cancer. (22nd May 2012)

• Record Type: Journal Article
• Authors: Kelly, Brian D.; Miller, Nicola; Healy, Nuala A.; Walsh, Kilian; Kerin, Michael J.
• Is Part Of: BJU international. Volume 111:Number 1(2013:Jan.)
• Page Start: 17
• Page End: 21
• Publication Date: 2012-05-22
• Subjects: Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/j.1464-410X.2012.11244.x
• Languages: English
• ISSNs: 1464-4096

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bju11244-sec-0001" sec-type="section"> <title>What's known on the subject? and What does the study add?</title> <p>MicroRNAs are small, single‐stranded RNA molecules that are stable in the circulation. These molecules have been identified as potential circulating biomarkers for several malignancies.</p> <p>In this review we provide a comprehensive overview of the publications that have identified dysregulated microRNAs in the circulation of men with prostate cancer.</p> </sec> <sec id="bju90003-sec-1001" sec-type="section"> <p> <list id="bju11244-list-0001" list-type="bullet"> <list-item> <p>MicroRNAs (miRNAs) are small non‐coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies.</p> </list-item> <list-item> <p>MiRNAs have the potential to be both a tissue‐ and blood‐based biomarker for cancer diagnosis, classification, prognosis and response to treatment.</p> </list-item> <list-item> <p>The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer.</p> </list-item> <list-item> <p>The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer.</p> </list-item> <list-item> <p>Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.</p> </list-item> </list> </p> </sec> </abstract>