New experimental probes for enzyme specificity and mechanism. (2023)

• Record Type: Book
• Further Information: Note: Edited by John P. Richard, Graham Moran.
• Editors: Richard, J. P (John P.); Moran, Graham
• Contents: 1. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis; 2. New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases; 3. Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase; 4. Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses; 5. Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces; 6. Kinetics and Mechanism for Reactions of Enzyme Pieces; 7. Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase; 8. Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase; 9. Innovative and emerging modalities of EGFR kinase inhibitors; 10. Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases; 11. Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase; 12. Probing the mechanism of flavin action in the oxidative decarboxylation catalyzed by salicylate hydroxylase; 13. Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase; 14. The Role of Protein Motions in Catalysis; 15. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis; 16. Adaptation of Transient State Methods to Reveal the Mechanism of Mammalian Dihydropyrimidine Dehydrogenase; 17. Charge Resonance in Enzyme Redox Reactions; 18. Motions and Allostery in Human Glucokinase; 19. Kinetic Dissection of CRISPR CAS-9; 20. Oxygenase PLP Chemistry; 21. Electron bifurcating flavoproteins
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2023
• Extent: 1 online resource (412 pages)
• Subjects: 572.70721; Enzymes -- Research -- Methodology; Molecular probes
• Languages: English
• ISBNs: 9780443152771
• Related ISBNs: 9780443152764
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.