Sulfurtransferases : essential enzymes for life /: essential enzymes for life. (2023)

• Record Type: Book
• Further Information: Note: Edited by Noriyuki Nagahara.
• Editors: Nagahara, Noriyuki
• Contents: Contributors Preface 1. 3-Mercaptopyruvate sulfurtransferase: the molecular and functional properties Noriyuki Nagahara and Takaaki Ito Adaptation of living organisms to oxidative and chemical environments Molecular evolution of sulfurtransferases MST and evolutionarily related enzymes of TST Molecular, kinetic, and functional properties of MST Properties of the promoter region of the MST gene Multiple functions of MST related to catalysis Possible production mechanism of H2S and polysulfide from MST Localization of MST in rat and mouse MST expression in mouse developmental stages MST-knockout mouse Future perspective Acknowledgments References Further reading 2. 3-Mercaptopyruvate sulfurtransferase: a review of past and present perspectives Y. Ogasawara Discovery and earlier characterization of 3-MST Comparison of 3-MST with thiosulfate sulfur transferase (rodanase) Purification and catalytic reaction Amino acid sequence and protein structure Physiological role of 3-MST 3-MST and rhodanese in selenium metabolism Methods for measuring 3-MP and 3-MST activities Clinical studies on 3-MST and the construction of 3-MST knockout mice Localization and significance of 3-MST in the central nervous system Involvement of 3-MST in sulfane sulfur (bound sulfur) generation References 3. The tales of fungal sulfurtransferases: lost, found, and stolen Sebastian Pilsyk References 4. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide (H2S), polysulfides (H2Sn), and other S-sulfurated signaling molecules Hideo Kimura Introduction 3MST produces H2S H2S and H2Sn regulate neuronal transmission 3MST as H2Sn producing enzyme Signaling via S-sulfuration of target proteins Energy formation versus its suppression by H2S Cytoprotection against oxidative stress Involvement of 3MST and H2S in the pathogenesis of schizophrenia Perspectives References 5. A persulfide shield: an endogenous reactive sulfur species in the forefront in the electrophile detoxification pathway Hisyam Abdul Hamid, Tsuyoshi Takata, Tetsuro Matsunaga and Takaaki Akaike Introduction Biosynthesis of biological polysulfides A “persulfide shield”: proposed as an electrophile defense mechanism RSS versus heavy metals RSS versus alkylating agents and xenobiotics Future directions of RSS-based research Acknowledgment References 6. Thiosulfate sulfurtransferase: a model of essential enzyme with potential applications in medicine and biotechnology Silvia Buonvino, Giulia Cinotti and Sonia Melino Introduction TST/rhodanese structure: a model for studying the protein folding TST in the cell metabolism Diseases related to TST dysregulation TST in biotechnology References Further reading 7. Chemical approaches to discover selective inhibitors of sulfurtransferases and transsulfuration enzymes Eita Sasaki and Kenjiro Hanaoka Introduction Widely used inhibitors of CBS, CSE, 3MST, and rhodanese Chemical approaches to discover new inhibitors Conclusions References 8. New insight into the role of TST-derived hydrogen sulfide, a key regulator of mesenteric homeostasis, in health and during chronic fructose intake Oleh Revenko, Yaroslav Pavlovsky, Iryna Kovalchuk, Maryana Savytska and Oksana Zayachkivska Introduction The beneficial role of TST-derived hydrogen sulfide Summary References Further reading 9. The S-adenosyl-L-methionine radical enzymes: the lipoic acid synthase and the biotin synthase Anna Bilska-Wilkosz Metabolic role of lipoic acid Biosynthesis of lipoic acid Metabolic role of biotin The biosynthetic pathway of biotin Radical S-adenosyl-L-methionine superfamily of enzymes The lipoyl synthase The biotin synthase References 10. Sulfur transferases in the pathways of molybdenum cofactor biosynthesis and tRNA thiolation in humans Silke Leimkühler and Moses Olalekan Ogunkola Introduction Thiolation of tRNA Thiocarboxylate formation on the URM1 protein Moco biosynthesis MOCS3 NFS1 TUM1 MTU1 CTU1 Conclusions References Index
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2023
• Extent: 1 online resource (472 pages)
• Subjects: 612.015192; Sulfotransferases; Enzymes -- Therapeutic use
• Languages: English
• ISBNs: 9780443188282
• Related ISBNs: 9780443188275
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