Inducing targeted protein degradation : from chemical biology to drug discovery and clinical applications /: from chemical biology to drug discovery and clinical applications. (2022)

• Record Type: Book
• Further Information: Note: Edited by Philipp Cromm.
• Editors: Cromm, Philipp
• Contents: Targeted Protein Degradation - The Story So Far; Cellular Principles of Targeted Protein Degradation; E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development; A Structural and Biophysical Perspective of Degrader Activity through Ternary Complex Formation; Computational Modeling of PROTAC Ternary Complexes and Linker Design; Molecular Glue Degraders: From Serendipity to Hunting and Design; Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases; Insights and Future Perspectives of Covalent Protein Degraders; Extending the Degradation Toolkit - mRNA targeting as Alternative Means to Affect Protein Levels; The Future of Heterobifunctional Compounds: PROTACs and Beyond; Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery; Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders; PROTAC? Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates
• Edition: 1st
• Publisher Details: Weinheim : Wiley-VCH
• Publication Date: 2022
• Extent: 1 online resource (368 pages)
• Subjects: 615.19; Drug development; Biochemistry; Proteolysis
• Languages: English
• ISBNs: 9783527836215
• Related ISBNs: 9783527350131
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.