Perinatal and developmental epigenetics. (2022)

• Record Type: Book
• Further Information: Note: Edited by Garima Singh.
• Editors: Singh, Garima
• Contents: Section I: The ever-growing complexity of epigenetic regulation of gene expression ; 1. Epigenetic regulation of gene expression: An overview of classical and recently discovered novel players: -Role of DNA methylation, Role of Histone modifications, Role of non-coding RNAs; 2. Epigenetic regulation of transposable elements and their impact on developmental processes; 3. Epigenetic regulation of germ cells; 4. Epigenetic regulation of cis-regulatory elements and transcription factors during development; 5. Genomic imprinting and developmental physiology: Intrauterine growth and postnatal period; 6. Metabolic regulation of epigenetic processes; 7. Role of RNA epigenetics in development; ; Section II: Epigenetic programming of the placenta regulates short-term and long-term health outcomes ; 8. Epigenetic regulation of placental function; 9. Role of placenta in developmental programming of sex-specific adult outcomes; 10. Epigenetic changes induced by Assisted Reproductive Technologies (ART) in the placenta and its effect on developmental outcomes; ; Section III: Epigenetics, hormones, sex and developmental programming ; 11. Epigenetic and hormone interaction and effect on gene regulation during prenatal and early postnatal life; 12. Role of epigenetics in shaping the sex difference in immune function during development; 13. Role of epigenetics in shaping sex differences in brain development and behavior; 14. Role of epigenetics in shaping sex differences in heart development and later life cardiovascular disease risk; ; Section IV: Epigenetic programming by adverse perinatal influences ; 15. Early life endocrine disruptors exposure and epigenetic programming; 16. Early life stress exposure and epigenetic programming; 17. Early life nutrition and epigenetic programming; 18. Early life air pollution exposure and epigenetic programming; 19. Early life substance abuse and epigenetic programming; ; Section V: Advancing translational epigenetic research ; 21. Modelling early life adversity in the laboratory –: Animal models, their advantages and challenges in extrapolating findings from animal studies to humans; 22. Clinical evidence of developmental programming due to early life exposures and long-term effects: Implications for public health; 23. Phenotypic plasticity: Adaptive vs Maladaptive response and epigenetic changes; 24. Epigenomics: A road to genome-wide characterization of epigenetic changes during development and identifying future individuals at risk of disease susceptibility; ; Section VI: Pharmacological and non-pharmacological approaches to reprogram the developmental programming to improve the health outcomes ; 26. Epigenetic signatures as biomarkers of early life experiences; 27. Environmental enrichment and its effect on modifying the epigenetic changes induced by early life adversity; 28. Dietary targeting of epigenome and its effect on early life adverse influences; 29. Early postnatal maternal care and epigenetic programming of HPA axis activity; 30. Emerging field of epigenetic editing: Implication for translational purposes for diseases with developmental origin and sex bias
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 618.32; Perinatology; Child development; Epigenetics
• Languages: English
• ISBNs: 9780128217863
• Related ISBNs: 9780128217856
• Notes: Note: Description based on CIP data; resource not viewed.
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