GPCRs as therapeutic targets. (2022)

• Record Type: Book
• Further Information: Note: Edited by Annette Gilchrist.
• Editors: Gilchrist, Annette
• Contents: Chapter 1 - An overview of G protein coupled receptors and their signaling partners Chapter 2 - Recent advances in orphan GPCRs research and therapeutic potential Chapter 3 - The Evolution of Our Understanding of GPCRs Chapter 4 - Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods Chapter 5 - Arrestin and G protein interactions with GPCRs: a structural perspective Chapter 6 - GPCRs at endosomes: sorting, signaling, and recycling Chapter 7 - Post-translational Control of GPCR Signaling Chapter 8 - GPCR Signaling from Intracellular Membranes Chapter 9 - Ten years of GPCR structures Chapter 10 - Activation of class B GPCR by peptide ligands: general structural aspects Chapter 11 - Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity Chapter 12 - Virtual Screening and Bioactivity Modeling for G Protein‐Coupled Receptors Chapter 13 - Importance of structure and dynamics in the rational drug design of G protein-coupled receptor (GPCR) modulators Chapter 14 - Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes Chapter 15 - G Protein-coupled Receptors in Metabolic Disease Chapter 16 - Endothelin Receptors in cerebrovascular diseases Chapter 17 - The calcium-sensing receptor (CaSR) in disease Chapter 18 - G protein-coupled receptors and their mutations in cancer – a focus on adenosine receptors Chapter 19 - Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders Chapter 20 - PTHR1 in bone Chapter 21 - Activators of G-protein Signaling in the normal and diseased kidney Chapter 22 - Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies Chapter 23 - Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs Chapter 24 - The Application of 19F NMR to Studies of Protein Function and Drug Screening Chapter 25 - Chapter X: Optical Approaches for Dissecting GPCR Signaling Chapter 26 - GPCR Signaling in Nanodomains: Lessons from Single-Molecule Microscopy
• Edition: 1st
• Publisher Details: Hoboken : John Wiley & Sons, Inc
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 615.6; Drug delivery systems; G proteins -- Receptors -- Effect of drugs on
• Languages: English
• ISBNs: 9781119564720
• Related ISBNs: 9781119564744
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.