Model-assisted Bayesian designs for dose finding and optimization : methods and applications /: methods and applications. (2022)

• Record Type: Book
• Further Information: Note: Ying Yuan, Ruitao Lin, J. Jack Lee.
• Authors: (Professor of biostatistics), Yuan, Ying; Lin, Ruitao; Lee, J. Jack
• Contents: 1. Bayesian Statistics and Adaptive Designs . 1.1. Basics of Bayesian Statistics. 1.2. Bayesian Adaptive Designs. 1.2. Bayesian Adaptive Designs. 2. Algorithm and Model-Based Dose Finding Designs . 2.1 Introduction. 2.2. Traditional 3+3 Design. 2.3. Cohort Expansion. 2.4 Accelerated Titration Design. 2.5. Continual Reassessment Method. 2.6. Bayesian Model Averaging CRM. 2.7. Escalation with Overdose Control. 2.8. Bayesian Logistic Regression Method. 2.9. Software. 3. Model-Assisted Dose Finding Designs. 3.1. Introduction. 3.2. Modified Toxicity Probability Interval Design. 3.3. Keyboard Design. 3.4. 3.4 Bayesian Optimal Interval (BOIN) Design. 3.5. Operating Characteristics. 3.6. Software and Case Study. 4. Drug-Combination Trials. 4.1. Introduction. 4.2. Model-based Designs. 4.3. Model-assisted Designs. 4.4. Operating Characteristics. 4.5. Software and Case Study. 5. Late-Onset Toxicity. 5.1. A Common Logistical Problem. 5.2. Late-Onset Toxicities. 5.3. TITE-CRM. 5.4. TITE-BOIN. 5.5. A Unified Approach using "Effective" Data. 5.6. TITE-keyboard and TITE-mTPI designs. 5.7. Software and Case Study. 6. Incorporating Historical Data. 6.1. Historical Data and Prior Information. 6.2. Informative BOIN (iBOIN). 6.3. iKeyboard Design. 6.4. Operating Characteristics. 6.5. Software and Case Study. 7. Multiple Toxicity Grades. 7.1. Multiple Toxicity Grades. 7.2. gBOIN Accounting for Toxicity Grade. 7.3. Multiple-toxicity BOIN. 7.4. Software and Illustration. 8. Finding Optimal Biological Dose. 8.1. Introduction. 8.2. EffTox design. 8.3. U-BOIN Design. 8.4. BOIN12 Design. 8.5. TITE-BOIN12 Design. 8.6. Other Model-Assisted Phase I/II Designs. 8.7. Software and Case Study. Bibliography. Index.
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 615.19; Drug development -- Statistical methods
• Languages: English
• ISBNs: 9780429626838; 9780429628474; 9780429052781
• Related ISBNs: 9780367146245
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
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