Pharmacology and toxicology of cytochrome P450 : 60th anniversary /: 60th anniversary. (2022)

• Record Type: Book
• Further Information: Note: Editor, Hiroshi Yamazaki.
• Editors: Yamazaki, Hiroshi
• Contents: Preface Hiroshi Yamazaki 1. Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future F. Peter Guengerich 2. Pharmacogenetics of the cytochromes P450: Selected pharmacological and toxicological aspects Ann K. Daly 3. Cytochromes P450 and metabolism of drugs and neurotoxins within the mammalian brain Marlaina R. Stocco and Rachel F. Tyndale 4. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences Michele M. Skopec, James R. Halpert and M. Denise Dearing 5. Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology Jacqueline Wen Hui Leow, Lloyd Wei Tat Tang and Eric Chun Yong Chan 6. Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites W. Griffith Humphreys 7. Use of engineered cytochrome P450s for accelerating drug discovery and development Raine E.S. Thomson, Stephlina A. D’Cunha, Martin A. Hayes and Elizabeth M.J. Gillam 8. Assessing cytochrome P450 function using genetically engineered mouse models Sarrah Hannon and Xinxin Ding 9. Expressions and functional activities of cytochrome P450 enzymes in human hepatocytes having sustainable reproducibility for in vitro phenotyping study Pamela Bachour-El Azzi, Christophe Chesné and Shotaro Uehara 10. Cytochrome P450s in chimeric mice with humanized liver Shotaro Uehara, Hiroshi Suemizu and Hiroshi Yamazaki 11. Polymorphic cytochromes P450 in non-human primates Yasuhiro Uno, Shotaro Uehara and Hiroshi Yamazaki 12. Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics Chie Emoto and Trevor N. Johnson 13. Cytochrome P450 polymorphism: From evolution to clinical use Magnus Ingelman-Sundberg
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 572.791; Cytochrome P-450
• Languages: English
• ISBNs: 9780323911108
• Related ISBNs: 9780323911092
• Notes: Note: Description based on CIP data; resource not viewed.
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