Allosteric modulation of G protein-coupled receptors. (2022)

• Record Type: Book
• Further Information: Note: Edited by Robert Laprairie.
• Editors: Laprairie, Robert
• Contents: Part I: Core Concepts ; 1. G Protein-Coupled Receptor-Dependent Signal Transduction: Orthosteric and Allosteric Mechanisms; 2. Analysis of Allosteric Modulation: Curve-Fitting and Modelling; 3. Critical Caveats: Probe-Dependence and Ligand Bias; 4. Ions as Allosteric Modulators; 5. Small Molecules as Allosteric Modulators; 6. Oligomerization: Protein-Protein Allosteric Effects; ; Part II: Critical Advances ; 7. Crystal Structures of G Protein-Coupled Receptors in Complex with Allosteric Modulators; 8. Receptor Subtype Selectivity: Muscarinic Receptors; 9. Receptor Subtype Selectivity: Opioid Receptors; 10. Lipid-based Allosteric Modulators; 11. Moving from Cells to Animals: Challenges of Studying Allosteric Modulators In vivo; 12. Disease Targets: Pain; 13. Disease Targets: Anxiety; 14. New Drug Targets: Clinical Translation of Allosteric Modulators, Cinacalcet; ; Part III: Key Methodologies ; 15. In silico Analysis of Allosteric Modulators; 16. Mapping Structure-Activity Relationships for Allosteric Modulators; 17. Kinetic Considerations of Allosteric Modulators; 18. Binding and Ligand Affinity; 19. Photoaffinity Ligands and the Metabotropic Glutamate Receptors; 20. Biosensors for the Study of Allosteric Modulation
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 612.01575; G proteins -- Receptors; Allosteric regulation
• Languages: English
• ISBNs: 9780128197721
• Related ISBNs: 9780128197714
• Notes: Note: Description based on CIP data; resource not viewed.
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