Anti-angiogenic drugs as chemosensitizers in cancer therapy. (2022)

• Record Type: Book
• Further Information: Note: Volume editor, Lucia Morbidelli.
• Editors: Morbidelli, Lucia
• Contents: 1. General Introduction to the book 2. Angiogenesis: definition and role, cellular and molecular mechanisms, redundancy of angiogenic modulators, receptors and converging signaling 3. Anti-angiogenic drugs (monotherapies): General characteristics; molecular mechanisms; efficacy and side effects 4. Anti-angiogenic drugs (combination therapies): molecular mechanisms; efficacy and side effects 5. Clinical applications in various cancers; state of the art of the approved protocols, ongoing clinical trials, gaps 6. Antiangiogenic drugs as chemosensitizer in colorectal cancer 7. Antiangiogenic drugs as chemosensitizer in lung cancer 8. Antiangiogenic drugs as chemosensitizer for upper GI cancer 9. Antiangiogenic drugs as chemosensitizer in breast cancer 10. Antiangiogenic drugs as chemosensitizer in renal and genitourinary cancer 11. Antiangiogenic drugs as chemosensitizer in skin cancer 12. Antiangiogenic drugs as chemosensitizer in brain tumors 13. Antiangiogenic drugs as chemosensitizer in circulating tumors 14. Antiangiogenic drugs and radiosensitization: state of the art on protocols and experimental studies 15. Resistance to combination treatments: mechanisms of resistance to antiangiogenic drugs and cross-talk with tumor cell mechanisms of resistance 16. Combination of antiangiogenic drugs with immunotherapies: efficacious synergism; side effects and limits 17. Prognostic and diagnostic biomarkers for therapy choice and to monitor antiangiogenic drug efficacy and toxicities 18. Antiangiogenic strategies: one target or multitarget inhibitors; synthetic compounds, gene therapy and natural products 19. Synthesis and application of dual inhibitors: rationale for development and state of the art of the studies 20. Metronomic therapy: mechanisms, advantages and approved protocols alone or in combination 21. Personalized medicine with tumor angiogenesis as diagnostic marker and therapeutic target 22. General Conclusions and future perspectives
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2022
• Extent: 1 online resource
• Subjects: 616.994061; Neovascularization inhibitors -- Therapeutic use; Cancer -- Chemotherapy; Tumors -- Blood-vessels
• Languages: English
• ISBNs: 9780323905565
• Related ISBNs: 9780323901901
• Notes: Note: Description based on CIP data; resource not viewed.
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