The chemical biology of long noncoding RNAs. ([2020])

• Record Type: Book
• Further Information: Note: Stefan Jurga, Jan Barciszewski, editors.
• Editors: Jurga, Stefan; Barciszewski, Jan
• Contents: Intro -- Preface -- Introduction -- Long Non-protein Coding RNAs -- Contents -- Long Non-coding RNAs Diversity in Form and Function: From Microbes to Humans -- 1 Introduction: Identification, Classification, and Properties of LncRNAs -- 2 Discovery of LncRNAs -- 2.1 Tiling Arrays -- 2.2 High-Throughput Sequencing Serial Analysis of Gene Expression (SAGE) -- 2.3 Histone Modification Signatures -- 2.4 Cap Analysis of Gene Expression (CAGE) -- 2.5 RNA Sequencing (RNA-Seq) -- 2.6 Direct RNA Sequencing (Oxford Nanopore) -- 3 Biogenesis of LncRNAs -- 3.1 Processing of LncRNAs 3.2 Regulation of LncRNA Transcription -- 3.3 Degradation of LncRNAs -- 3.4 LncRNA Subcellular Localization -- 3.5 LncRNA Structure and Structure-Mediated Interactions -- 4 Human LncRNAs -- 4.1 X-inactive Specific Transcript (XIST) -- 4.2 MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) -- 4.3 HOX Transcript Antisense RNA (HOTAIR) -- 4.4 Steroid Receptor RNA Activator (SRA) -- 4.5 Maternally Expressed 3 (MEG3) -- 5 Plant LncRNAs -- 5.1 Cold of Winter-Induced Non-coding RNA (COLDAIR) -- 5.2 Cold-Induced Long Antisense Intragenic RNA (COOLAIR) 5.3 Cold of Winter-Induced Non-coding RNA from the Promoter (COLDWRAP) -- 5.4 Auxin-Regulated Promoter Loop RNA (APOLO) -- 6 Bacterial LncRNAs -- 6.1 Ornate, Large, Extremophilic RNAs (OLE) -- 6.2 Giant, Ornate, Lake- and Lactobacillales-Derived (GOLLD) -- 6.3 HNH Endonuclease-Associated RNA and ORF (HEARO RNA) -- 7 Viral LncRNAs -- 7.1 Adenovirus Virus-Associated RNAs (VA RNAs) -- 7.2 Kaposiś Sarcoma-Associated Herpesvirus (KSHV) Polyadenylated Nuclear RNA (PAN) -- 7.3 Human Cytomegalovirus LncRNAs -- 7.4 Human Immunodeficiency Virus-1 Antisense RNA (ASP) 7.5 Subgenomic Flaviviral RNAs (sfRNAs) -- 8 LncRNA and Therapy -- 9 Conclusions -- References -- Evolving Roles of Long Noncoding RNAs -- 1 Introduction -- 2 The Classification, Localization, and Structures of lncRNAs -- 2.1 Definition and Classification of lncRNAs -- 2.1.1 lncRNAs -- 2.1.2 lncRNAs Classification -- 2.2 Subcellular Localization -- 2.3 Structural Studies -- 2.3.1 Structural Determination of lncRNAs and Potential Structural Analysis Techniques -- 2.3.2 lncRNA Secondary Structure Predication -- 2.3.3 Predict lncRNA Tertiary Structure -- 2.3.4 Structure-Function Relationships 3 Mechanisms of Action and Physiological Functions -- 3.1 lncRNA Interaction with Proteins -- 3.2 lncRNA Interaction with DNA -- 3.3 lncRNA Interaction with RNAs -- 4 lncRNAs as Potential Biomarkers and Therapeutic Targets in Neurological Disorders -- 4.1 Alzheimerś Disease (AD) -- 4.2 Spinal Muscular Atrophy (SMA) -- 4.3 Spinal Cord Injury (SCI) -- 4.4 Huntingtonś Disease (HD) -- 4.5 Angelman Syndrome (AS) -- 4.6 Schizophrenia (SZ) -- 4.7 Dravet Syndrome (DS) -- 4.8 Parkinsonś Disease (PD) -- 5 Advances in Antisense Oligonucleotide (ASO) Chemistry for Targeted Delivery
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2020
• Extent: 1 online resource (x, 544 pages), illustrations (some color)
• Subjects: 572.8/8; 611.01816; 599.935; Non-coding RNA; Nucleic acids; Biomedical engineering; RNA, Long Noncoding -- chemistry; Biomedical engineering; Human genetics; Nucleic acids; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030447434
• Related ISBNs: 303044743X; 9783030447427; 3030447421
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed December 3, 2020).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.