Selected reaction monitoring mass spectrometry (SRM-MS) in proteomics : a comprehensive view /: a comprehensive view. (2020)

• Record Type: Book
• Further Information: Note: Mahmud Hossain.
• Other Names: Hossain, Mahmud
• Contents: Intro -- Preface -- Contents -- Abbreviations -- Chapter 1: Introduction -- 1.1 Introduction to Mass Spectrometry -- 1.1.1 Mass Spectrometer -- 1.1.2 Mass Spectrum -- 1.2 General Applications of Mass Spectrometry -- 1.2.1 Proteomics -- 1.2.2 Other Biological Applications -- 1.2.3 Pharmaceuticals -- 1.2.4 Clinical -- 1.2.5 Environmental -- 1.2.6 Geological -- 1.3 History of Mass Spectrometry -- 1.3.1 The Early Years of Mass Spectrometry -- 1.3.2 Use of Mass Spectrometry Pre- and Post-World War II Era -- 1.3.3 Beginning of Biomolecule Research by Mass Spectrometry 1.3.4 Paradigm Shift in Mass Spectrometry Analysis -- 1.3.5 The Development of Proteomics -- References -- Chapter 2: The Mass Spectrometer and Its Components -- 2.1 Major Components of the Mass Spectrometer -- 2.1.1 Ion Source -- 2.1.1.1 Electron Ionization (EI) -- 2.1.1.2 Chemical Ionization (CI) -- 2.1.1.3 Electrospray Ionization (ESI) -- 2.1.1.4 Matrix-Assisted Laser Desorption/Ionization (MALDI) -- 2.1.2 Mass Analyzers -- 2.1.2.1 Quadrupole Mass Analyzers -- 2.1.2.2 Quadrupole Ion Trap Mass Analyzer -- 2.1.2.3 Time-of-Flight Mass Analyzer -- 2.1.2.4 FT-ICR Mass Analyzers 2.1.2.5 Orbitrap Mass Analyzer -- 2.1.3 Detectors of Mass Spectrometry -- 2.1.3.1 Characteristics of an Ideal Detector -- 2.1.3.2 Photoplate Detector -- 2.1.3.3 Faraday Cup Detector -- 2.1.3.4 Electron Multiplier Detectors -- 2.1.3.5 Microchannel Plate (MCP) Detector -- 2.1.3.6 Microsphere Plate (MSP) Detector -- 2.1.4 Other Components of Mass Spectrometer: Vacuum System -- 2.2 Tandem Mass Spectrometry (MS/MS) -- 2.2.1 MS/MS Instrumentation -- 2.2.2 Scan Modes in Tandem Mass Spectrometry -- 2.3 Dissociation Methods in Mass Spectrometry -- 2.3.1 Collision-Induced Dissociation (CID) 2.3.2 High-Energy Collisional Dissociation (HCD) -- 2.3.3 Electron Capture Dissociation -- 2.3.4 Electron Transfer Dissociation (ETD) -- References -- Chapter 3: Selected Reaction Monitoring Mass Spectrometry -- 3.1 Proteomics -- 3.1.1 Bottom-Up, Top-Down, and Middle-Down Proteomics -- 3.1.2 Shotgun/Discovery and Targeted Proteomics -- 3.2 Selected Reaction Monitoring Mass Spectrometry (SRM-MS) -- 3.2.1 SRM-MS in Comparison to Non-MS Analytical Technique -- 3.2.2 Instrumentation for SRM-MS -- 3.2.3 Commercial Triple Quadrupole Instruments -- 3.2.4 Distinctive Features of SRM-MS 3.3 Variations of the Conventional SRM-MS -- 3.3.1 Constrained SRM-MS -- 3.3.2 MRM3 -- 3.3.3 Dynamic SRM-MS -- 3.3.4 Photo-SRM -- 3.3.5 MALDI-SRM -- 3.3.6 MSIA-SRM -- 3.4 Other Targeted MS Methodologies -- 3.4.1 Selected Ion Monitoring -- 3.4.2 Accurate Inclusion Mass Screening (AIMS) -- 3.4.3 pSRM (pseudo-Selected Reaction Monitoring) -- 3.4.4 Parallel Reaction Monitoring -- 3.4.5 Data-Independent Acquisition (DIA) -- 3.4.6 Comparison of SRM with PRM and DIA/SWATH -- References -- Chapter 4: Development of SRM-MS Experiment -- 4.1 General Workflow of a Proteomic SRM-MS Assay
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 572.6; Proteomics; Mass spectrometry; Spectrum analysis; Cheminformatics; Electronic books
• Languages: English
• ISBNs: 9783030534332; 3030534332
• Related ISBNs: 3030534324; 9783030534325
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.