Drug delivery challenges and novel therapeutic approaches for retinal diseases. ([2020])

• Record Type: Book
• Other Names: Cioffi, Christopher L
• Contents: Intro -- Preface -- Contents -- Introduction: Overview of the Human Eye, Mammalian Retina, and the Retinoid Visual Cycle -- 1 Introduction -- 1.1 The Anterior Segment of the Human Eye -- 1.1.1 The Anterior Chamber: Cornea -- 1.1.2 The Anterior Chamber: Iris -- 1.1.3 The Posterior Chamber: The Lens -- 1.1.4 The Posterior Chamber: The Ciliary Body -- 1.1.5 The Ciliary Muscle -- 1.1.6 The Ciliary Process -- 1.1.7 The Aqueous Humor -- 1.1.8 The Blood-Aqueous Barrier -- 1.2 The Posterior Segment of the Human Eye -- 1.2.1 The Vitreous Humor -- 1.2.2 The Retina -- 1.2.3 The Retinal Vasculature 1.2.4 The Optic Nerve -- 1.2.5 The Sclera -- 2 The Components of the Mammalian Retina -- 2.1 The Photoreceptors -- 2.2 Histology of the Mammalian Retina -- 2.2.1 Retinal Bipolar Cells -- 2.2.2 Retinal Ganglion Cells -- 2.2.3 Horizontal and Amacrine Cells -- 2.2.4 Retinal Glial Cells -- 2.2.5 The Layers of the Retina -- 2.2.6 The Macula of the Retina -- 2.3 The Retinal Pigment Epithelium -- 2.3.1 Outer Blood-Retinal Barrier -- 2.3.2 Phagocytosis of Photoreceptor Outer Segments -- 2.3.3 Absorption of Excess Light -- 2.3.4 Maintaining Ocular Immune Privilege 2.3.5 Maintaining Homeostasis of Supporting Tissues -- 2.3.6 Participation in the Visual Cycle -- 3 The Retinoid Visual Cycle and Phototransduction -- 3.1 The Canonical Retinoid Visual Cycle and Phototransduction -- 3.2 The Cone-Specific Visual Cycle -- 3.3 Proteins of the Visual Cycle -- 3.3.1 Transport Proteins -- RBP4-TTR -- CRBP -- CRALBP -- IRBP -- 3.3.2 Enzymes -- Lecithin-Retinol Acyltransferase: LRAT -- RPE65 -- Retinol Dehydrogenases (RDHs) -- 3.3.3 The ABCA4 Transporter -- References -- Ocular Pharmacokinetics and Drug Delivery Challenges -- 1 Introduction -- 2 Important Ocular Anatomy 2.1 Gross Anatomy -- 2.2 Tear Film -- 2.3 Sclera -- 2.4 Choroid -- 2.5 Retina -- 2.6 Vitreous -- 2.7 Blood-Retinal Barrier -- 2.8 Melanin Binding -- 3 Ocular Pharmacokinetics -- 3.1 Basic Pharmacokinetics -- 3.1.1 Distribution -- 3.1.2 Metabolism -- 3.1.3 Elimination -- Elimination via the Anterior Route -- Elimination via the Posterior Route -- 3.2 Topical Therapy -- 3.3 Drug Development and Pharmacokinetics -- 3.3.1 Pegaptanib -- 3.3.2 Bevacizumab -- 3.3.3 Ranibizumab -- 3.3.4 Aflibercept -- 3.3.5 Brolucizumab -- 3.3.6 Small-Molecular-Weight Molecules -- 4 Pharmacodynamics 4.1 Preclinical Studies -- 4.1.1 In Vitro Studies -- 4.1.2 In Vivo Studies -- 5 Challenges to Drug Delivery -- 5.1 Drugs that Possess Extended Durations of Action -- 5.2 Encapsulated Cell Technology -- 5.3 Gene Therapy -- 5.4 Refillable Implant -- 5.5 Small Molecule Sustained Release Devices -- 6 Conclusion -- References -- Models of Pathologies Associated with Age-Related Macular Degeneration and Their Utilities in Drug Discovery -- 1 Introduction -- 2 AMD-Relevant In Vitro Cell Modeling -- 2.1 Primary Culture Cells -- 2.1.1 Primary Cultures of Human Fetal RPE (hfRPE) and Adult RPE
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 617.7/35; Retina -- Diseases -- Treatment; Pharmaceutical chemistry; Ophthalmology; Pharmaceutical technology; Gene therapy; Ophthalmology; Pharmaceutical technology; Gene therapy; Biochemistry; Medical -- Ophthalmology; Medical -- Pharmacy; Medical -- Genetics; Science -- Chemistry -- Clinical; Electronic books
• Languages: English
• ISBNs: 9783030566197; 3030566196
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.