Principles of Virology. (2020)

• Record Type: Book
• Further Information: Note: Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Theodora Hatziioannou, Anna Marie Skalka.
• Authors: Flint, Jane; Racaniello, Vincent R; Rall, Glenn F; Hatziioannou, Theodora; Skalka, Anna Marie
• Contents: Volume 1 ; Preface Acknowledgments About the Authors PART I: The Science of Virology 1 Foundations Luria’s Credo Viruses Defined Why We Study Viruses Viruses Are Everywhere Viruses Infect All Living Things Viruses Can Cause Human Disease Viruses Can Be Beneficial Viruses “R” Us Viruses Can Cross Species Boundaries Viruses Are Unique Tools To Study Biology Virus Prehistory Viral Infections in Antiquity The First Vaccines Microorganisms as Pathogenic Agents Discovery of Viruses The Defining Properties of Viruses The Structural Simplicity of Virus Particles The Intracellular Parasitism of Viruses Cataloging Animal Viruses The Classical System Classification by Genome Type: the Baltimore System A Common Strategy for Viral Propagation Perspectives References Study Questions 2 The Infectious Cycle Introduction The Infectious Cycle The Cell Entering Cells Viral RNA Synthesis Viral Protein Synthesis Viral Genome Replication Assembly of Progeny Virus Particles Viral Pathogenesis Overcoming Host Defenses Cultivation of Viruses Cell Culture Embryonated Eggs Laboratory Animals Assay of Viruses Measurement of Infectious Units Efficiency of Plating Measurement of Virus Particles Viral Reproduction: the Burst Concept The One-Step Growth Cycle One-Step Growth Analysis: a Valuable Tool for Studying Animal Viruses Global Analysis DNA Microarrays Mass Spectrometry Protein-Protein Interactions Single-Cell Virology Perspectives References Study Questions PART II: Molecular Biology 3 Genomes and Genetics Introduction Genome Principles and the Baltimore System Structure and Complexity of Viral Genomes DNA Genomes RNA Genomes What Do Viral Genomes Look Like? Coding Strategies What Can Viral Sequences Tell Us? The “Big and Small” of Viral Genomes: Does Size Matter? The Origin of Viral Genomes Genetic Analysis of Viruses Classical Genetic Methods Engineering Mutations into Viral Genomes Engineering Viral Genomes: Viral Vectors Perspectives References Study Questions 4 Structure Introduction Functions of the Virion Nomenclature Methods for Studying Virus Structure Building a Protective Coat Helical Structures Capsids with Icosahedral Symmetry Other Capsid Architectures Packaging the Nucleic Acid Genome Direct Contact of the Genome with a Protein Shell Packaging by Specialized Viral Proteins Packaging by Cellular Proteins Viruses with Envelopes Viral Envelope Components Simple Enveloped Viruses: Direct Contact of External Proteins with the Capsid or Nucleocapsid Enveloped Viruses with an Additional Protein Layer Large Viruses with Multiple Structural Elements Particles with Helical or Icosahedral Parts Alternative Architectures Other Components of Virions Enzymes Other Viral Proteins Cellular Macromolecules Mechanical Properties of Virus Particles Investigation of Mechanical Properties of Virus Particles Stabilization and Destabilization of Virus Particles Perspectives References Study Questions 5 Attachment and Entry Introduction Attachment of Virus Particles to Cells General Principles Identification of Receptors for Virus Particles Virus-Receptor Interactions Entry into Cells Virus-induced Signaling via Cell Receptors Routes of entry Membrane Fusion Intracellular Trafficking and Uncoating Movement of Viral and Subviral Particles within Cells Uncoating of enveloped viruses Uncoating of non-enveloped viruses Import of Viral Genomes into the Nucleus The Nuclear Pore Complex Nuclear Localization Signals Import of RNA Genomes Import of DNA Genomes Import of Retroviral Genomes Perspectives References Study Questions 6 Synthesis of RNA from RNA Templates Introduction The Nature of the RNA Template Secondary Structures in Viral RNA Naked or Nucleocapsid RNA The RNA Synthesis Machinery Identification of RNA-Dependent RNA Polymerases Three-Dimensional Structures of RNA-Dependent RNA Polymerases Mechanisms of RNA Synthesis Initiation Capping Elongation Functions of Additional Polymerase Domains RNA polymerase Oligomerization Template Specificity Unwinding the RNA Template Role of Cellular Proteins Paradigms for Viral RNA Synthesis (+) Strand RNA Synthesis of Nested Subgenomic mRNAs (−) Strand RNA Ambisense RNA Double-Stranded RNA Unique Mechanisms of mRNA and Genome Synthesis of Hepatitis Delta Satellite Virus Do Ribosomes and RNA Polymerases Collide? Origins of Diversity in RNA Virus Genomes Misincorporation of Nucleotides Segment Reassortment and RNA Recombination RNA Editing Perspectives References Study Questions 7 Synthesis of RNA from DNA Templates Introduction Properties of Cellular RNA Polymerases That Transcribe Viral DNA Some Viral Genomes Must Be Converted to Templates Suitable for Transcription Transcription by RNA Polymerase II Regulation of RNA Polymerase II Transcription Common Properties of Proteins That Regulate Transcription Transcription of Viral DNA Templates by the Cellular Machinery Alone Viral Proteins That Govern Transcription of DNA Templates Patterns of Regulation The Human Immunodeficiency Virus Type 1 Tat Protein Autoregulates Transcription The Transcriptional Cascades of DNA Viruses Entry into One of Two Alternative Transcriptional Programs Transcription of Viral Genes by RNA Polymerase III The VA-RNA I Promoter Inhibition of the Cellular Transcriptional Machinery Unusual Functions of Cellular Transcription Components in Virus-Infected Cells Viral DNA-Dependent RNA Polymerases Perspectives References Study Questions 8 Processing Introduction Covalent Modification during Viral Pre-mRNA Processing Capping the 5′ Ends of Viral mRNA Synthesis of 3′ Poly(A) Segments of Viral mRNA Internal Methylation of Adenosine Residues Splicing of Viral Pre-mRNA Regulated Processing of Viral Pre-mRNA Editing of Viral mRNAs Export of RNAs from the Nucleus The Cellular Export Machinery Export of Viral mRNA Posttranscriptional Regulation of Viral or Cellular Gene Expression by Viral Proteins Temporal Control of Viral Gene Expression Viral Proteins Can Inhibit Cellular mRNA Production Regulation of Turnover of Viral and Cellu
• Edition: 5th
• Publisher Details: ASM Press
• Publication Date: 2020
• Extent: 1 online resource (1136 pages)
• Languages: English
• ISBNs: 9781683673583
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.