Protein degradation with new chemical modalities : successful strategies in drug discovery and chemical biology /: successful strategies in drug discovery and chemical biology. (2020)
- Record Type:
- Book
- Title:
- Protein degradation with new chemical modalities : successful strategies in drug discovery and chemical biology /: successful strategies in drug discovery and chemical biology. (2020)
- Main Title:
- Protein degradation with new chemical modalities : successful strategies in drug discovery and chemical biology
- Further Information:
- Note: Edited by Hilmar Weinmann, Craig Crews.
- Editors:
- Weinmann, Hilmar
Crews, Craig - Contents:
- PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?; Structural and Biophysical Principles of Degrader Ternary Complexes; Immediate and Selective Control of Protein Abundance using the dTAG System; Developing Pharmacokinetic/Pharmacodynamic Relationships with PROTACs; New Activities of CELMoDs, Cereblon E3 Ligase Modulating Drugs; Structure-based PROTACs Design; Plate-Based High Throughput Cellular Degradation Assays to Identify PROTACS Molecules and Protein Degraders; PROTAC Targeting BTK for the Treatment of Ibrutinib-Resistant B-Cell Malignancies; An Efficient Approach Toward Drugging Undruggable Targets; E3-Mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes; Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering; Deubiquitinase Inhibitors: An Emerging Therapeutic Class; Targeting Translation Regulation for the Development of Novel Drugs; Classes, Modes-of-action and Selection of New Modalities in Drug Discovery; Small Molecule Targeted Degradation of RNA
- Edition:
- 1st
- Publisher Details:
- Cambridge : Royal Society of Chemistry
- Publication Date:
- 2020
- Extent:
- 1 online resource
- Subjects:
- 615.19
Drugs -- Design
Proteolysis - Languages:
- English
- ISBNs:
- 9781839160691
9781839160776 - Related ISBNs:
- 9781788016865
- Notes:
- Note: Description based on CIP data; resource not viewed.
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.564843
- Ingest File:
- 03_195.xml