Programmed cell death in animals and plants. (2020)

• Record Type: Book
• Further Information: Note: Edited by John Bryant, Jeff Garland, S.G. Hughes.
• Editors: Bryant, J. A; Garland, Jeff; Hughes, S. G (Steve G.)
• Contents: Contributors -- Abbreviations -- Preface -- 1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant -- Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote -- The molecular mechanisms of programmed cell death in Caenorhabditis elegans -- Comparison with mammalian apoptosis -- Plants, from Arabidopsis to Zinnia -- General conclusions -- 2 Caspases - at the cutting edge of cell death /H.R. Stennicke -- Introduction -- Caspases and their properties -- Structure of the caspases -- Activation and regulation of the caspases -- Evolution of the caspases -- 3 Modulation of death receptor signalling /P. Schneider and J.Tschopp -- Introduction -- Death receptors and apoptosis -- Activation of death receptors by death ligands -- Decoy receptors -- Inhibition of death receptor by FLIP -- Conclusion -- 4 The role of the Bcl-2 family in the modulation of apoptosis /C. Pepper and P. Bentley -- Introduction -- Bcl-2 family: life or death promoters -- Function of the Bcl-2 family proteins -- Cellular control of Bcl-2 family proteins -- Over-expression of Bcl-2 family proteins and chemoresistance -- Drug resistance in B-CLL -- Strategies for inhibiting Bcl-2 function in B-CLL -- Conclusions -- 5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson -- Introduction -- Induction of apoptosis by cytotoxic T cells and natural killer cells -- How does granzyme B gain access to the interior of target cells? -- Molecular targets of granzyme B -- Regulation of granzyme B activity -- The intracellular regulation of granzyme B by PI-9 -- The role of intracellular serpins in cell growth and death -- Conclusions -- 6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran -- Introduction -- The mitochondrial permeability transition -- Mitochondria and apoptosis -- 7 Regulation of apoptosis by cell metabolism, cytochrome c and the cytoskeleton /J.M. Garland -- Introduction -- Apoptosis: the general scene -- Apoptosis and the cytoskeleton -- Apoptosis and metabolism -- Measurement of apoptosis -- Apoptosis in a defined haematopoietic cell system -- IL3 dependency: a universal model for life /death signalling -- Final comments -- 8 Organelle-specific death pathways /K. T. Pun and R.J. Brown -- Introduction -- Bcl-2 family proteins are present in multiple subcellular compartments -- ER dysfunction induces apoptosis -- Apoptosis initiated at other intracellular locations -- The role of subcellular apoptotic complexes -- Concluding remarks -- 9 Telomeres, telomerase and cellular immortalization /C.J. Jones -- Introduction -- Cellular or replicative senescence -- Telomeres: form and function -- Telomere-binding proteins -- Telomerase -- Telomerase and cancer -- Telomerase-knockout mouse -- Immortalization of normal cells by telomerase -- Future prospects -- 10 Back from the brink: plant senescence and its reversibility /H. Thomas and I. Donnison -- Many ways to get dead -- Organ senescence has a cellular basis -- How do senescing cells change colour? -- Senescence is an energy-demanding oxidative process -- Proteins are remobilized in cell senescence - but how? -- Senescence is programmed -- Senescence is regulated at the transcriptional and post-transcriptional level -- Senescence is reversible -- Post-mortem -- 11 Senescence and cell death in Brassica napus and Arabidopsis /V. B uchanan-Wollaston and K. Morris -- What is senescence in plants? -- Senescence and programmed cell death -- When is senescence induced? -- What happens during senescence? -- Analysis of leaf senescence in B. napus -- Links between different types of senescence -- Expression of the senescence-enhanced metallothionein gene, LSC54 -- Expression of other senescence-enhanced genes -- The screen for mu tan ts -- Conclusions -- 12 Cytokinin and its receptors /R. Hooley -- Introduction -- Cytokinins and leaf senescence -- Cytokinin receptors -- 13 Ethylene-triggered cell death during aerenchyma formation in roots /M.C. Drew, C.-J. He and P.W. Morgan -- Introduction -- Patterns of aerenchyma formation -- Aerenchyma function -- Ethylene biosynthesis and induction of cell death -- Ethylene signal transduction pathways -- Programmed cell death -- 14 Targeted cell death in xylogenesis /M.C. McCann, N.J. Stacey and K. Roberts -- Introduction -- Plant programmed cell death -- Cell death is blocked by a cathepsin B inhibitor -- Conclusion -- 15 Abscission and dehiscence /].A. Roberts -- Introduction -- Events associated with abscission -- Abscission and PCD -- Dehiscence -- Events associated with dehiscence -- Dehiscence and PCD -- PCD and the manipulation of dehiscence -- Conclusions -- 16 Regulation of cell cycle arrest and cell death - alternative responses to DNA damage /C. Norbury -- Introduction -- A role for p53 in the G2 DNA damage checkpoint -- ATM and cellular responses to DNA damage -- Resistance to checkpoint-suppressing drugs -- 17 Tissue transglutaminase in cell death /M. Griffin and E. Verderio -- Introduction -- The role of tissue transglutaminase in apoptosis -- Molecular bases of tissue transglutaminase regulation during cell death: role of the enzyme in embryogenesis -- Role of calcium in apoptosis and in the activation of tissue transglutaminase -- Tissue transglutaminase-induced cell death: a novel death pathway -- Conclusion -- 18 Pathways used by adenovirus ElB 19K to inhibit apoptosis /K. Degenhardt, D. Perez and E. White -- Introduction -- E1B 19Kp53-mediated apoptosis -- The Fas and TNF-R1 pathways are blocked by E1B 19K -- E1B 19K inhibits the caspase adapter molecules CED-4 and Apaf-1 -- E1B 19K interacts with Btf, a novel transcriptional repressor -- Future directions -- 19 Tumour cell death /I.D. Bowen and F. Amin -- Introduction -- Cell death in tumours -- Tumour necrosis factor a and tumour cell death -- The role of p53 and Bcl-2 in tumour cell apoptosis -- Non-apoptotic programmed cell death? -- 20 Controlling apoptosis: implications for carcinogenesis /A.R. Clarke -- Introduction -- p53 -- Msh2 -- Msh2 andp53 -- Conclusions -- 21 Type I interferons inhibit the resolution of chronic inflammation /D. Scheel-Toellner, A.N. Akbar, D. Pilling, C.H. Orteu, C.D. Buckley, K. Wang, PR. Webb, J.M. Lord and M. Salmon -- Introduction -- The resolution of immune responses is mediated by apoptosis -- Pathways leading to T-cell apoptosis -- Resolution of T-cell mediated immune responses in healthy individuals -- The resolution of immune responses is inhibited in chronic inflammation -- Stromal rescue is mediated by IFN-13 -- Inhibition of spontaneous neutrophil apoptosis in vitro and in the rheumatoid joint -- Apoptosis of stromal cells in rheumatoid arthritis -- How does type I interferon inhibit T-cell apoptosis? -- Conclusion -- 22 Death of plant cells and their contribution to rumen function /A.H. Kingston-Smith and M.K. T heodorou -- An introduction to the rumen ecosystem -- Potential responses of plant metabolism to the rumen -- Cell death in plants -- Post-ingestion plant metabolism in the rumen; does it resemble cell death? -- Future prospects for improved livestock agriculture -- 23 Postscript: some concluding observations and speculations /S. G. Hughes and J.M. Garland -- Index -- A colour plate appears on pages 239 and 240.
• Edition: 1st
• Publisher Details: New York : Garland Science
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 571.936; Apoptosis
• Languages: English
• ISBNs: 9781000144659
• Related ISBNs: 9781000102345; 9781000119510; 9781003076889
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.