Bacterial type III protein secretion systems. (2020)

• Record Type: Book
• Further Information: Note: Samuel Wagner, Jorge E. Galan, editors.
• Other Names: Wagner, Samuel, 1978-; Galán, Jorge E
• Contents: Intro -- Preface -- Contents -- 210 A Unified Nomenclature for Injectisome-Type Type III Secretion Systems -- Abstract -- References -- 168 Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion -- Abstract -- 1 Introduction -- 2 T3SS Regulation on the Transcriptional Level -- 2.1 Control by Central Transcriptional Activators -- 2.2 Transcriptional Control of the Key T3SS Regulators -- 2.3 Silencing and Activation of T3SS Master Regulator Expression by Modulator Proteins -- 3 T3SS Regulation on the Post-transcriptional Level -- 3.1 Control of Translation 3.1.1 Sensory RNAs-RNA Thermometers -- 3.1.2 Translational Control by CsrA/RsmA RNA-Binding Proteins -- 3.2 Control of T3SS mRNA Structures and Stability-Influence of Helicases and RNases -- 3.3 Regulatory RNAs -- 3.4 Feedback Control Mechanisms Through Secreted Effectors or Anti-sigma Factors -- 4 T3SS Regulation on the Protein Level -- 4.1 Changing Binding Partners -- 4.2 Modulation or Modification of T3SS Regulatory Components -- 5 Conclusions and Future Perspectives -- References -- 164 Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System -- Abstract 1 Introduction -- 2 Structure and Function of the Injectisome -- 3 What Drives Protein Assemblies? -- 4 Assembly of the IM Export Apparatus -- 5 Assembly of the Membrane Rings -- 6 Assembly of the Cytosolic Complex -- 7 Assembly of the Needle -- 8 The First Substrate Switch and Assembly of the Needle Tip -- 9 The Second Substrate Switch and Assembly of the Translocon -- 10 Stability and Dynamics of the Injectisome -- 11 Concluding Remarks -- References -- 178 The Structure of the Type III Secretion System Needle Complex -- Abstract -- 1 Visualizing the Needle Complex 2 A Structural Blueprint of the Needle Complex -- 3 The Individual Building Blocks of the Needle Complex -- 3.1 The Inner Membrane Protein SctD -- 3.2 The Second Inner Membrane Protein SctJ -- 3.3 The Outer Membrane Protein SctC -- 3.4 The Needle Adaptor Protein SctI -- 3.5 The Needle Filament Protein SctF -- 3.6 The Tip Complex Protein SctA -- 3.7 The Export Apparatus Proteins SctV, SctR, SctS, SctT and SctU -- 4 Assembly, Conformational Flexibility and Substrate Secretion -- 5 Future Directions -- References 170 Molecular Organization and Assembly of the Export Apparatus of Flagellar Type III Secretion Systems -- Abstract -- 1 Introduction -- 2 Structure of the Transmembrane Export Gate Complex -- 2.1 FlhA Ring Structure -- 2.2 FlhB -- 2.3 Core Structure of the Export Gate Complex -- 3 Cytoplasmic ATPase Ring Complex -- 4 Sorting Platform -- 5 Assembly of the Type III Protein Export Apparatus -- 6 Conclusion -- References -- 192 Structures of Type III Secretion System Needle Filaments -- Abstract -- 1 Introduction -- 2 The T3SS Needle: Biological Functions
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 579.3/165; Pathogenic bacteria; Bacteria -- Physiology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030521233; 3030521230
• Related ISBNs: 3030521222; 9783030521226
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.