Cytokines of the lung. (2020)

• Record Type: Book
• Further Information: Note: Edited by Jason Kelley.
• Authors: Kelley, J
• Editors: Kelley, Jason, 1943-
• Contents: Introduction -- Preface -- Contributors -- Part I MITOGENIC CYTOKINES -- 1. Platelet-Derived Growth Factor /James P. Fabisiak and Jason Kelley -- I. Introduction -- II. Protein Structure -- III. Gene Structure, Organization, and Processing -- IV. PDGF Receptors -- V. Biological Properties of PDGFs -- VI. Cellular Sources of PDGF -- VII. Regulation of PDGF -- VIII. PDGF in Lung Disease -- IX. Conclusions -- References -- 2. Fibroblast Growth Factors /David Moscatelli -- I. Introduction -- IL History of FGFs -- III. Structural Properties -- IV. FGF Receptors -- V. Interaction with Extracellular Matrix -- VI. Biological Properties -- VIL The Role of FGFs in Tumor Formation -- VIII. FGFs in Lung Biology -- References -- 3. Insulin-Like Growth Factors /Alan D. Stiles, Billie M. Moats-Staats, and George Z. Retsch-Bogart -- I. Introduction -- II. IGF Peptides -- III. IGF Genes and Transcripts -- IV. IGF Receptors -- V. IGF-Binding Proteins -- VI. Actions of IGFs -- VIL Role of IGFs in Fetal Growth -- VIII. Role of IGFs in Postnatal Growth -- IX. IGFs and Lung -- X. Summary -- References -- 4. Transforming Growth Factor-, 8 /Jason Kelley -- I. Introduction -- II. The TGF-β Family of Proteins -- III. Biosynthesis of TGF-β -- IV. Gene Structure of TGF-, Bs -- V. Control of TGF-β Gene Expression -- VI. Autoinduction of TGF-β Gene Expression -- VII. Activation of TGF-β Protein -- VIII. Receptors for TGF-β -- IX. Signaling Pathways for TGF-β -- X. TGF-β as a Mitogen -- XL Antiproliferative Effects of TGF-β -- XII. TGF-β and Extracellular Matrix -- XIII. Interactions Between TGF-β and Other Cytokines -- XIV. TGF-β and the Immune System -- xv. TGF-β in Monocyte-Macrophages, Granulocytes, and Mast Cells -- XVI. TGF-β in Fibroblasts -- XVII. Assays for TGF-β -- XVIII. TGF-β in Lung -- XIX. TGF-β in Remodeling and Fibrosis -- xx. Future Directions -- References -- 5. Transforming Growth Factor-a and Epidermal Growth Factor /David K. Madtes -- I. Introduction -- II. The Growth Factor Precursor Molecules -- III. The Growth Factor Genes -- IV. Structure-Function Relationships of the Growth Factors -- V. The EGF Receptor -- VI. Biological Responses to TGF-a and EGF -- VII. The Role of TGF-a and EGF in Lung Development -- VIII. The Role of TGF-a and EGF in Pulmonary Neoplasia -- IX. The Role of TGF-a and EGF in Lung Repair -- X. Conclusion -- References -- Part II PROINFLAMMATORY CYTOKINES -- 6. Interleukin-I /Timothy R. Aksamit and Gary W. Hunninghake -- I. Introduction -- II. Historical Perspective -- III. Structure -- IV. Synthesis -- V. IL-1 Receptor -- VI. Signal Transduction -- VIL IL-1 Inhibitors -- VIII. IL-1 Effects -- IX. Interactions with Other Cytokines -- X. IL-1 and the Lung -- XI. Summary -- References -- 7. lnterleukin-6 and the Lung /Ralph J. Zitnick and Jack A. Elias -- I. Introduction -- II. The IL-6 Protein -- III. The IL-6 Gene: Structure and Regulation -- IV. The IL-6 Receptor -- V. Biological Effects of IL-6 -- VI. IL-6 in Human Homeostasis -- VII. IL-6 in the Lung -- VIII. Summary -- References -- 8. Interleukin-8 /Robert M. Strieter, Theodore J. Standiford, Mark W. Rolfe, and Steven L. Kunkel -- I. Introduction -- II. Chemotactic Factors -- III. Isolation of IL-8 -- IV. Structure of IL-8 -- V. IL-8 Supergene Family -- VI. Physicochemical and Biological Effects of IL-8 -- VII. IL-8 Receptor and Signal Transduction -- VIII. Cytokine Networks and the Expression of IL-8 -- IX. Regulation of IL-8 -- X. The Potential Role of IL-8 in Pulmonary Disease -- References -- 9. Tumor Necrosis Factor /Thomas R. Ulich -- I. The Tumor Necrosis Factors: Historical Review -- II. TNF as a Mediator of Local Inflammation and Septic Shock -- III. Pulmonary Sources of TNF Production -- IV. Target Cells for TNF within the Lung -- V. The Proinflammatory Role of TNF in the Lung In Vivo -- VI. Down-Regulation of TNF -- VIL Summary and Future Directions -- References -- 10. Enzyme-Releasing Peptide /Allen B. Cohen, Edmund J. Miller, and Cassandra MacArthur -- I. Introduction -- II. Neutrophil Granule Enzymes and Their Release -- III. The Enzyme-Releasing Peptide -- IV. Other Similar Agents -- V. Conclusion -- References -- 11. Macrophage Inflammatory Protein-I /Barbara Sherry and Anthony Cerami -- I. Introduction -- II. Isolation, Cloning, and Preliminary Characterization of MIP-1 Peptides -- III. Cloning and Characterization of MIP-la and MIP-1, 8 cDNAs -- IV. Proinflammatory Nature of MIP-1 -- V. Modulatory Effects of MIP-1 on Hematopoietic Cell Development -- VI. Preliminary Receptor Characterization of the MIP-1 a and MIP-1, 8 Receptors -- VII. Conclusions -- References -- Part III CYTOKINES IN THE LUNG -- 12. Myeloid Growth Factors in the Lung /Jack Gauldie, Mane / Jordana, and Gerard Cox -- I. Colony-Stimulating Factors -- IL Respiratory Cell-Derived CSFs -- III. Effects of CSFs on Immature Inflammatory Cells -- IV. Effects of CSFs on Mature Inflammatory Cells -- V. Implications and Future Directions -- References -- Contents -- 13. Fibroblast-Pneumonocyte Factor /Barry T. Smith and Martin Post -- I. Introduction -- II. Epithelial-Mesenchymal Interactions -- III. Fibroblast-Pneumonocyte Factor -- IV. Conclusion -- References -- 14. Cytokines and Alveolar Type II Cells /Ralph J. Panos -- I. Introduction -- II. Surfactant Synthesis -- III. Surfactant Secretion -- IV. Surfactant Proteins -- V. Type II Cell Proliferation -- VI. Production of Cytokines by Alveolar Type II Cells -- VII. Other Interactions of Cytokines and Type II Cells -- VIII. Conclusions -- References -- Part IV CYTOKINES WITH SPECIAL EFFECTS -- 15. Cytokine-Binding Proteins /James C. Bonner and Arnold R. Brody -- I. Introduction -- II. Cytokine-a-Macroglobulin Interactions -- ill. The Insulin-Like Growth Factor-Binding Proteins -- IV. Other Cytokine-Binding Proteins -- V. Cytokine-Binding Proteins in Lung Disease -- VI. Conclusions -- References -- 16. Cytokine Effects on Extracellular Matrix /Ganesh Raghu and Michael Kinsella -- I. Introduction -- II. Extracellular Matrix in the Normal Lung -- III. Extracellular Matrix in the Abnormal Lung -- IV. Direct Effects of Cytokines on Extracellular Matrix Synthesis -- V. Indirect Effects of Cytokines on Extracellular Matrix Production -- VI. Summary -- VII. Perspectives and Future Directions -- References -- Author Index -- Subject Index.
• Edition: 1st
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2020
• Extent: 1 online resource, illustrations
• Subjects: 612.24; Lungs -- Molecular aspects; Cytokines
• Languages: English
• ISBNs: 9781000148855
• Related ISBNs: 9781000105643; 9781000127522; 9781003066927
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
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