SAR : side effects and drug design /: side effects and drug design. (2020)

• Record Type: Book
• Further Information: Note: Eric J. Lien.
• Authors: Lien, Eric J, 1937-
• Contents: About the Series -- Preface -- 1. Theories of Drug Action -- I. Evolution of Concepts of Drug-Receptor Interaction -- II. Occupancy Theory -- III. Rate Theory -- IV. Induced-Fit Theory: Allosteric Site and Cooperative Effect -- V. Macromolecular Perturbation Theory -- VI. The Second Messenger Concept -- VII. Active-Site-Directed Irreversible Inhibitors -- VIII. Mechanism- and Pharmacophore-Based Drug Design -- References -- 2. Improvement of Therapeutic Agents by Molecular Modification -- I. Modification of the Absorption of Drugs -- II. Optimization of Time Course and Distribution by Chemical Modification -- III. Modification of the Intrinsic Pharmacological Activity -- IV. Minimization of Biodegradation of Drugs -- V. Improvement of Acceptability by Chemical Modification -- References -- 3. Quantitative Structure-Activity Relationship -- I. Dose-Response Curve and Quantitative Measurement of Biological Activity -- II. Kinetics Versus Thermodynamics -- III. Structure-Acidity-Solubility Relationship -- IV. Multiple Regression Analysis and Numerical Presentation of Physicochemical Parameters -- V. QSAR of Convulsants, Anticonvulsants, and Depressants -- VI. QSAR of Narcotic Analgetics -- VII. QSAR of Antihistamines and Anticholinergics -- VIII. QSAR of Stereoisomers -- References -- 4. Ribonucleotide Reductase Inhibitors as Antiviral and Anticancer Agents -- I. Ribonucleotide Reductase (Ribonucleoside Diphosphate Reductase) as a Biochemical Target -- II. Inhibitors of RR -- References -- 5. Chemical Structure and Side Effects -- I. Extrapyramidal Syndrome -- II. Bone Marrow Depression and Blood Dyscrasias -- III. Hepatotoxicity -- IV. Nephrotoxicity -- V. Ototoxicity -- VI. Skin Sensitization and Drug-Induced Eosinophilia 281 VII. Glaucoma and Cataracts -- VIII. Carcinogenicity of Anticancer Drugs -- References -- Appendix -- Index.
• Edition: 1st
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 615.7; Drugs -- Structure-activity relationships; Drugs -- Side effects; Drugs -- Design
• Languages: English
• ISBNs: 9781000146899
• Related ISBNs: 9781000103465; 9781000129168; 9781003065715
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.