Histone modifications in therapy. (2020)

• Record Type: Book
• Further Information: Note: Edited by Pedro Castelo-Branco, Carmen Jeronimo.
• Editors: Castelo-Branco, Pedro; Jeronimo, Carmen
• Contents: 1. Therapeutic perspectives for targeting histone modifications in mental retardation 2. Role of histone acetylation and methylation in depression 3. Epigenetic treatment of neurodegenerative diseases 4. Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease 5. A prospective view of targeting histone modifications for Autism Spectrum Disorder Section II. Targeting histone modifications for cancer treatment 6. HDAC inhibitors in cancer therapy 7. Lysine methyltransferase drug targets in cancer 8. Targeting EZH2 in cancer 9. Targeting DOT1L for mixed lineage rearranged leukemia 10. Targeting bromodomains in cancer treatment and other diseases 11. Histone demethylase inhibitors and their potential in cancer treatment 12. IDH mutations in cancer and progress toward development of targeted therapeutics Section III. Targeting histone modifications for cardiovascular diseases and diabetes 13. Histone modification for cardiovascular prevention and therapeutics 14. Modulation of histone modification as a potential preventive and therapeutic approach for cardiovascular diseases 15. Epigenetics as an emerging approach to treat atherosclerosis 16. The potentiality of epigenetic drugs for diabetes and obesity 17. Epigenetic modifications for diabetic retinopathy 18. Targeting histone modifications in cancer immunotherapy 19. Epigenetic drug development for autoimmune and inflammatory diseases 20. Perspectives on epigenetic-based immune intervention for rheumatic diseases 21. The potential for targeted rewriting of epigenetic marks in Chronic obstructive pulmonary disease as a new therapeutic approach Section V. Targeting histone modifications for infectious disease 22. The therapeutic potential of epigenetic manipulation during infectious diseases 23. Targeting histone deacetylases for bacterial infections 24. Targeting histone methyltransferases EZH2/1 to suppress infection by diverse viral pathogens
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 572.66; Histones
• Languages: English
• ISBNs: 9780128167403
• Related ISBNs: 9780128164228
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.