Recent advances in endometrial cancer. (2020)

• Record Type: Book
• Further Information: Note: Sumita Mehta, Bindiya Gupta, editors.
• Other Names: Mehta, Sumita; Gupta, Bindiya
• Contents: Intro -- Preface -- Contents -- About the Editors -- Contributors -- Part I: Trends and Etiology of Endometrial Cancer -- 1: Changing Trends in the Epidemiology of Endometrial Cancer -- 1.1 Introduction -- 1.2 Type I and II Carcinomas -- 1.2.1 Pathophysiologic and Molecular Distinctions -- 1.2.2 Type II-Specific Epidemiologic Factors -- 1.3 Age -- 1.4 Race/Ethnicity -- 1.4.1 Blacks -- 1.4.2 Hispanics -- 1.4.3 Asians/Pacific Islanders -- 1.4.4 American Indians/Alaska Natives -- 1.4.5 Global Trends -- 1.5 Endogenous Estrogen Exposure -- 1.5.1 Pathophysiologic Mechanisms of Disease 1.5.2 Chronic Anovulation -- 1.5.3 Obesity -- 1.5.4 Early Menarche and Late Menopause -- 1.5.5 Estrogen-Secreting Tumors -- 1.6 Exogenous Estrogen Exposure -- 1.6.1 Unopposed Estrogen Therapy -- 1.6.2 Postmenopausal Hormone Replacement Therapy -- 1.6.3 Tamoxifen, Other SERMs, and Aromatase Inhibitors -- 1.7 Genetic Syndromes -- 1.7.1 Family History -- 1.7.2 Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) -- 1.7.3 Cowden Syndrome -- 1.7.4 BRCA1 and BRCA2 Mutations -- 1.8 Fertility-Associated Factors -- 1.8.1 Nulliparity and Infertility -- 1.8.2 Breastfeeding 1.8.3 Contraceptives -- 1.8.4 Tubal Ligation -- 1.9 Other Associated Factors -- 1.9.1 Diet and Phytoestrogens -- 1.9.2 Ultraviolet Radiation, Calcium, and Vitamin D -- 1.9.3 Exercise -- 1.9.4 Diabetes and Hypertension -- 1.9.5 Cigarette Smoking -- 1.9.6 Alcohol -- 1.9.7 Coffee and Tea -- 1.9.8 Aspirin -- 1.10 Summary -- References -- 2: Cytogenetic Mechanisms in Endometrial Cancer -- 2.1 Introduction -- 2.2 Classification of EC -- 2.2.1 Clinicopathological Classification -- 2.2.2 Genetic Classification -- 2.3 Role of Estrogen 2.3.1 Imbalance Between Estrogen-Induced Endometrial Proliferation and Mismatch Repair System -- 2.3.2 Dysregulation of Different Genetic Factors by Estrogen -- 2.4 Mechanisms Involved in Genesis of EC at Cytogenetic Level -- 2.4.1 Epigenetics -- 2.4.2 Abnormal Mismatch Repair (MMR) System -- 2.4.3 Gene Mutation -- 2.4.3.1 Tumor Suppressor Genes -- 2.4.3.2 Oncogenes -- 2.4.4 MicroRNA -- 2.5 Cytogenetic Basis of Different Characteristics of EC -- 2.5.1 Myometrial Invasion -- 2.5.2 Apoptosis Resistance -- 2.5.3 Resistance to Ionizing Radiation Treatment -- 2.6 Conclusion -- References 3: Endometrial Precancers: Diagnosis and Management -- 3.1 Introduction -- 3.2 Etiology -- 3.3 Classification -- 3.3.1 Endometrial Intraepithelial Neoplasia -- 3.4 Comparison Between WHO and EIN Classification -- 3.5 Clinical Features -- 3.6 Diagnosis -- 3.6.1 Ultrasound -- 3.6.2 Office Endometrial Biopsy -- 3.6.3 Hysteroscopy and Targeted Biopsy -- 3.6.4 CT/MRI/Biomarkers -- 3.7 Management -- 3.7.1 Observation -- 3.7.2 Medical Management -- 3.7.2.1 Progestin -- 3.7.2.2 Clomiphene or Aromatase Inhibitors -- 3.7.2.3 Metformin -- 3.7.2.4 GnRH Agonist -- 3.7.2.5 Danazol
• Publisher Details: Singapore : Springer
• Publication Date: 2020
• Extent: 1 online resource (306 p.)
• Subjects: 616.99/466; Endometrium -- Cancer -- Diagnosis; Endometrium -- Cancer -- Treatment; Endometrium -- Cancer -- Surgery; Electronic books; Electronic books
• Languages: English
• ISBNs: 9789811553172; 9811553173
• Related ISBNs: 9811553165; 9789811553165
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.