GM3 Signaling. (2020)

• Record Type: Book
• Further Information: Note: Cheorl-Ho Kim.
• Authors: Kim, Cheorl-Ho
• Contents: 1. History of sialic acids, gangliosides and GM3.- 2. Synthesis of GM3.- 3. Molecular localization of GM3 in cells.- 4. Basic function of GM3 as an interacting molecule.- 5. GD3 mimetics with a neurite forming capacity.- 6. GM3 as a pathogenic infection receptor.- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis.- 8. GM3 has an anti-tumor capacity.- 9. GM3 suppresses tumor angiogenesis.- 10. Interaction between EGFR and GM3.- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling.- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase.- 13. VEGFR-GM3 interaction in angiogenesis.- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis.- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation.- 16. Galectin-1 promotes tumor growth and escapes immune surveillance.- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing.- 18. GM3, caveolin-1 and insulin receptor in insulin resistance.- 19. GM3 suppresses arthritis.- 20. GM3 protects cochlear hair cells and hearing from corti degeneration.- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1.- 22. GM3 in leukemic cells into terminal differentiation.- 23. α2, 3-Sialyllactose (3SL) or α2, 6-sialyllactose (6SL) of GM3 glycan in innate immunity.
• Publisher Details: Singapore : Springer
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource (138 pages)
• Subjects: Medicine; Gene expression; Cancer research; Genetics; Biochemistry; Cell membranes ; Medical -- Oncology; Science -- Life Sciences -- Genetics & Genomics; Science -- Life Sciences -- Biochemistry; Science -- Life Sciences -- Cytology; Oncology; Genetics (non-medical); Biochemistry; Cellular biology (cytology); Medical -- Genetics; Medical genetics
• Languages: English
• ISBNs: 9789811556524
• Related ISBNs: 9789811556517
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.