Tumor microenvironment molecular players.: molecular players. Part A (2020)
- Record Type:
- Book
- Title:
- Tumor microenvironment molecular players.: molecular players. Part A (2020)
- Main Title:
- Tumor microenvironment molecular players.
- Other Titles:
- Molecular players
- Further Information:
- Note: Alexander Birbrair, editor.
- Other Names:
- Birbrair, Alexander
- Contents:
- Intro -- Preface -- Contents -- Contributors -- 1 Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers -- 1.1 Introduction -- 1.2 Processing of Cathepsin D -- 1.3 Physiological Roles of CathD as Both an Intracellular and Extracellular Protein -- 1.4 Expression of CathD in Cancer -- 1.5 Role of CathD in Tumor Progression -- 1.5.1 Proteolytic-Dependent Roles -- 1.5.2 Proteolytic-Independent Roles -- 1.6 Future Perspective -- 1.6.1 Potential Anti-TME CathD Therapeutic Strategies -- 1.7 Conclusions -- References -- 2 Galectins in the Tumor Microenvironment: Focuson Galectin-1 2.1 Galectins: A Diverse Family with Important Biological Functions -- 2.2 Glycosylation and Gal-1 in the Tumor Microenvironment -- 2.3 Gal-1 Expression in the Tumor Stroma -- 2.4 Gal-1 and Fibroblast Activation -- 2.5 Gal-1 in the Tumor Endothelium -- 2.6 Gal-1 in Tumor Immune Evasion -- 2.7 Other Galectins in the Tumor Microenvironment -- 2.8 Future Trends and Directions -- References -- 3 Iron in the Tumor Microenvironment -- 3.1 Iron homeostasis in physiological conditions -- 3.2 Iron Metabolism in Cancer Cells -- 3.3 Iron therapeutics in cancer -- 3.4 Conclusion and Future Perspectives 4.7.4 Oxygen in a Fine-Grained Simulation of the Tumor Microenvironment -- 4.8 Conclusions -- References -- 5 Roles for Phospholipase D1 in the TumorMicroenvironment -- 5.1 Introduction -- 5.2 Roles for PLD, and in Particular PLD1, in the Tumor Microenvironment -- 5.2.1 Neoangiogenesis andIntro -- Preface -- Contents -- Contributors -- 1 Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers -- 1.1 Introduction -- 1.2 Processing of Cathepsin D -- 1.3 Physiological Roles of CathD as Both an Intracellular and Extracellular Protein -- 1.4 Expression of CathD in Cancer -- 1.5 Role of CathD in Tumor Progression -- 1.5.1 Proteolytic-Dependent Roles -- 1.5.2 Proteolytic-Independent Roles -- 1.6 Future Perspective -- 1.6.1 Potential Anti-TME CathD Therapeutic Strategies -- 1.7 Conclusions -- References -- 2 Galectins in the Tumor Microenvironment: Focuson Galectin-1 2.1 Galectins: A Diverse Family with Important Biological Functions -- 2.2 Glycosylation and Gal-1 in the Tumor Microenvironment -- 2.3 Gal-1 Expression in the Tumor Stroma -- 2.4 Gal-1 and Fibroblast Activation -- 2.5 Gal-1 in the Tumor Endothelium -- 2.6 Gal-1 in Tumor Immune Evasion -- 2.7 Other Galectins in the Tumor Microenvironment -- 2.8 Future Trends and Directions -- References -- 3 Iron in the Tumor Microenvironment -- 3.1 Iron homeostasis in physiological conditions -- 3.2 Iron Metabolism in Cancer Cells -- 3.3 Iron therapeutics in cancer -- 3.4 Conclusion and Future Perspectives 4.7.4 Oxygen in a Fine-Grained Simulation of the Tumor Microenvironment -- 4.8 Conclusions -- References -- 5 Roles for Phospholipase D1 in the TumorMicroenvironment -- 5.1 Introduction -- 5.2 Roles for PLD, and in Particular PLD1, in the Tumor Microenvironment -- 5.2.1 Neoangiogenesis and Platelet-Facilitated Metastasis -- 5.2.2 Tumor Cell Energetics -- 5.2.3 Secretion of Chemokines and Factors That Promote Tumor Growth -- 5.2.4 Interaction of Tumors with the Immune System -- 5.2.5 Exosomes and Phospholipase D1 -- 5.2.6 Cautionary Tales -- 5.2.6.1 Inhibitors 5.2.6.2 Generalizability of Studies -- 5.3 Summary -- References -- 6 Leptin in Tumor Microenvironment -- 6.1 Introduction: Biology of Leptin -- 6.1.1 LEP Gene and Structure of Leptin Protein -- 6.1.2 Leptin Receptors -- 6.1.3 Leptin Signaling -- 6.2 Source of Leptin in Tumor Microenvironment -- 6.2.1 Leptin from Blood -- 6.2.2 Autocrine Leptin in Peripheral Tissues -- 6.2.3 Regulation of Leptin in Tumor Microenvironment -- 6.3 Role of Leptin in Tumor Microenvironment -- 6.3.1 Cell Targets of Leptin -- 6.3.2 Vascular Effects of Leptin -- 6.3.3 Leptin Modulates Sex Hormone Metabolism … (more)
- Publisher Details:
- Cham : Springer
- Publication Date:
- 2020
- Extent:
- 1 online resource (183 p.)
- Subjects:
- 571.9/78
Tumors -- Molecular aspects
Cancer -- Molecular aspects
Electronic books - Languages:
- English
- ISBNs:
- 9783030430931
3030430936 - Related ISBNs:
- 3030430928
9783030430924 - Notes:
- Note: References -- 4 Oxygen in the Tumor Microenvironment: Mathematical and Numerical Modeling -- 4.1 Introduction -- 4.2 The Fourier Problem -- 4.3 Linear Model of Oxygen Diffusion and Consumption -- 4.4 The Near-Cylindrical Geometry of Blood Vessels -- 4.5 Dealing with Dead Cells: Tumor Cords -- 4.6 Comparison with Experimental Data -- 4.7 Into the Future: Numerical Simulations of Vascularized Tumors -- 4.7.1 The Oxygen Concentration Field of Simulated Vascularized Tumors Embedded in Normal Tissue -- 4.7.2 Continuum Description of Tumor Tissue -- 4.7.3 Simulation of Individual Tumor Cells
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.513378
- Ingest File:
- 03_095.xml