Disorders-differences of sex development an integrated approach to management /: an integrated approach to management. (2020)

• Record Type: Book
• Further Information: Note: John M. Hutson, Sonia R. Grover, Michele A. O'Connell, Aurore Bouty, Chloe A. Hanna, editors.
• Other Names: Hutson, John M; Grover, Sonia R; O'Connell, Michele A; Bouty, Aurore; Hanna, Chloe A
• Contents: Intro -- Preface for the Second Edition -- Acknowledgements for the Second Edition -- Contents -- About the Editors -- 1: Introduction: Changing Landscapes -- 1.1 Background -- 1.1.1 Terminology -- 1.1.2 Recent History of DSD -- 1.1.3 Clinical Definition of DSD -- 1.1.4 Incidence of DSD -- 1.1.5 Clinical Care: Historical Perspective and Changes Over Time -- 1.1.6 Human Rights and DSD: Where to from Here? -- References -- 2: The Molecular Basis of Sex Determination and Differentiation: Implications for Understanding DSD -- 2.1 Formation of the Bi-potential Gonad 2.10 Genetics and DSD -- 2.11 Conclusion -- References -- 3: Embryology of the Human Genital Tract -- 3.1 The Urogenital Ridge -- 3.1.1 Wolffian and Müllerian Duct Development -- 3.2 Sexual Differentiation -- 3.2.1 Testosterone -- 3.2.2 Anti-Müllerian Hormone (AMH or MIS) -- 3.2.3 Insulin-Like Hormone (INSL3) -- 3.3 External Genitalia -- 3.4 Gonadal Descent -- References -- 4: Hormones Regulating Sex Development -- 4.1 Introduction -- 4.2 Testicular Hormones -- 4.2.1 Testosterone Synthesis -- 4.2.2 Androgen Receptor -- 4.2.3 Control of Testosterone Levels 4.2.4 Anti-Müllerian Hormone (AMH) -- 4.2.5 Insulin-Like Hormone 3 (INSL3) -- 4.3 Ovarian Hormones -- 4.4 The Placenta -- 4.5 The Foetal Hypothalamic-Pituitary Axis -- 4.6 Postnatal Hormone Levels and Implications (Fig. 4.4) -- References -- 5: Embryology in DSD -- 5.1 Sex Determination -- 5.2 46, XY Complete Gonadal Dysgenesis -- 5.3 Incomplete Testicular Differentiation (and Mixed Gonadal Dysgenesis) -- 5.4 Anatomy of Caudal Internal Ducts in DSD -- 5.5 Placental Failure -- 5.6 Failure of the Hypothalamic-Pituitary-Gonadal Axis -- 5.7 Failure of Hormone Action -- 5.7.1 INSL3 5.7.2 AMH -- 5.7.3 Androgen -- 5.8 Morphogenesis of the Genitalia (See Also Chap. 9) -- 5.9 Internal Genital Tract -- 5.9.1 Wolffian Ducts -- 5.9.1.1 In the Female -- 5.9.1.2 In the Male -- Epididymis -- Vas Deferens -- Seminal Vesicles (SV) -- Cysts -- Agenesis and Hypoplasia -- 5.9.2 Müllerian Ducts -- 5.9.2.1 In the Female -- Anomalies of Development -- Aplasia and Hypoplasia -- Unicornuate Uterus -- Anomalies of Fusion -- Uterus Didelphys -- Bicornuate Uterus -- Anomalies of Septal Reabsorption -- Septate Uterus -- Arcuate Uterus -- 5.9.2.2 In the male -- 5.10 External Genitalia
• Edition: 2nd ed
• Publisher Details: Singapore : Springer
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 618.92/65; Sexual disorders in children; Gender identity disorders in children; Generative organs -- Abnormalities; Paediatric medicine; Medical genetics; Medical -- Pediatrics; Medical -- Genetics; Gender identity disorders in children; Generative organs -- Abnormalities; Sexual disorders in children; Electronic books
• Languages: English
• ISBNs: 9789811378645; 9811378649
• Related ISBNs: 9811378630; 9789811378638
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.