Senolytics in disease, ageing and longevity. (2020)

• Record Type: Book
• Further Information: Note: Edited by Daniel Muñoz-Espin, Marco Demaria.
• Other Names: Muñoz-Espin, Daniel; Demaria, Marco
• Contents: Part I: Origins and Development of Senotherapies -- Chapter 1. Senolytic drug development -- Chapter 2. Discovery of Senolytics and the pathway to early phase clinical trials -- Part II: The Impact of Senotherapies: from Regeneration to Aging -- Chapter 3. Interconnection between cellular senescence, regeneration and ageing in salamanders -- Chapter 4. Senolytics target senescent cells and improve aging and age-related diseases -- Chapter 5. Senotherapy of cancer -- Part III: Understanding and Targeting the Senescent Surfaceome -- Chapter 6. Targeted senolytic strategies based on the senescent surfaceome -- Chapter 7. Senolysis and senostasis through the plasma membrane -- Part IV: Novel Senescence-Associated Markers and Targets -- Chapter 8. In situ detection of miRNAs in senescent cells in archival material -- Chapter 9. Novel probes and carriers to target senescent cells -- Chapter 10. Potential applications of aptamers for targeting senescent cells -- Chapter 11. Mitochondria: potential targets for interventions to counteract senescence.
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource (222 pages)
• Subjects: 571.8; Cells -- Aging; Cellular Senescence; Cells -- Aging
• Languages: English
• ISBNs: 9783030449032
• Related ISBNs: 9783030449025
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.