Optimization of trustworthy biomolecular quantitative analysis using cyber-physical microfluidic platforms. (2020)

• Record Type: Book
• Further Information: Note: Mohamed Ibrahim, Krishnendu Chakrabarty.
• Authors: Ibrahim, Mohamed; Chakrabarty, Krishnendu
• Contents: 1 Introduction; 1.1 Overview of Digital Microfluidics; 1.2 Overview of Continuous-Flow Microfluidics; 1.3 Design Automation and Optimization of Micro fluidic Biochips; 1.4 Cyber-physical Adaptation for Quantitative Analysis; 1.5 Security Assessment of Biomolecular Quantitative Analysis; 1.6 Proposed Research Methodology; 1.7 Book Outline; I Real-Time Execution of Multi-Sample Biomolecular Analysis; 2 Synthesis for Multiple Sample Pathways: Gene-Expression Analysis; 2.1 Benchtop Protocol for Gene-Expression Analysis; 2.2 Digital Microfluidics for Gene-Expression Analysis; 2.3 Spatial Reconfiguration; 2.4 Shared-Resource Allocation; 2.5 Firmware for Quantitative Analysis; 2.6 Simulation Results; 2.7 Chapter Summary; 3 Synthesis of Protocols with Temporal Constraints: Epigenetic Analysis; 3.1 Miniaturization of Epigenetic-Regulation Analysis; 3.2 System Model; 3.3 Task Assignment and Scheduling; 3.4 Simulation Results and Experimental Demonstration; 3.5 Chapter Summary; 4 A Micro fluidics-Driven Cloud Service: Genomic Association Studies; 4.1 Background; 4.2 Biological Pathway of Gene Expression and Omic Data; 4.3 Case Study: Integrative Multi-Omic Investigation of Breast Cancer; 4.4 The Proposed Framework: BioCyBig; 4.5 BioCyBig Application Stack; 4.6 Design of Microfluidics for Genomic Association Studies; 4.7 Distributed-System Interfacing and Integration; 4.8 Chapter Summary; II High-Throughput Single-Cell Analysis; 5 Synthesis of Protocols with Indexed Samples: Single-Cell Analysis; 5.1 Hybrid Platform and Single-Cell Analysis; 5.2 Mapping to Algorithmic Models; 5.3 Co-Synthesis Methodology; 5.4 Valve-Based Synthesizer; 5.5 Protocol Modeling Using Markov Chains; 5.6 Simulation Results; 5.7 Chapter Summary; 6 Timing-Driven Synthesis with Pin Constraints: Single-Cell Screening; 6.1 Preliminaries; 6.2 Multiplexed Control and Delay; 6.3 Sortex: Synthesis Solution; 6.4 Experimental Results; 6.5 Chapter Summary; III Parameter-Space Exploration and Error Recovery; 7 Synthesis for Parameter-Space Exploration: Synthetic Bio-circuits; 7.1 Background; 7.2 PSE Based on MEDA Biochips; 7.3 Sampling of Concentration Factor Space; 7.4 Synthesis Methodology; 7.5 High-Level Synthesis; 7.6 Physical-Level Synthesis; 7.7 Simulation Results; 7.8 Chapter Summary; 8 Fault-Tolerant Realization of Biomolecular Assays; 8.1 Physical Defects and Prior Error-Recovery Solutions; 8.2 Adaptation of the C5 Architecture to Error Recovery; 8.3 System Design; 8.4 Dictionary-Based Error Recovery; 8.5 Experiment Results and Demonstration; 8.6 Chapter Summary; IV Security Vulnerabilities and Countermeasures; 9 Security Vulnerabilities of Quantitative-Analysis Frame-works; 9.1 Threats Assessment of DMFBs; 9.2 Manipulation Attacks on Glucose-Test Results; 9.3 Attacks in the Presence of Cyber-Physical Integration; 9.4 DNA-Forgery Attacks on DNA Preparation; 9.5 Chapter Summary; 10 Security Countermeasures of Quantitative-Analysis Frame-works; 10.1 Microfluidic Encryption; 10.2 Aging Reinforces DMFB Security; 10.3 Encryption Security Analysis and Simulation Results; 10.4 DNA Barcoding as a Biochemical-Level Defense Mechanism; 10.5 Benchtop Demonstration of DNA Barcoding; 10.6 Chapter Summary; 11 Conclusion and Future Outlook; 11.1 Book Summary; 11.2 Future Research Directions; Appendix A Proof of Theorem 5.1: A Fully Connected Routing Crossbar; Appendix B Modeling a Fully Connected Routing Crossbar; Appendix C Proof of Lemma 6.1: Derivation of Control Delay Vector Appendix D Proof of Theorem 6.1: Derivation of Control Latency; Appendix E Proof of Lemma 7.1: Properties of Aliquot-Generation Trees; E.1 Overlapping-Subproblems Property; E.2 Optimal-Substructure Property; Appendix F Proof of Theorem 7.1: Recursion in Aliquot-Generation Trees; Bibliography
• Edition: 1st
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2020
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 532.05; Microfluidics
• Languages: English
• ISBNs: 9781000082708; 9781000082661; 9781003053187
• Related ISBNs: 9780367223526
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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