Design and Analysis of Subgroups with Biopharmaceutical Applications. (2020)

• Record Type: Book
• Further Information: Note: Naitee Ting, Joseph C. Cappelleri, Shuyen Ho, (Din) Ding-Geng Chen.
• Editors: Ting, Naitee; Cappelleri, Joseph C; Ho, Shuyen; Chen, (Din) Ding-Geng
• Contents: 1. Data-driven and Confirmatory Subgroup Analysis in Clinical Trials.- 2. Subgroup Analysis – A View from Industry.- 3. Biomarker-Targeted Confirmatory Trials.- 4. Considerations on Subgroup Analysis in Design and Analysis of Multi-Regional Clinical Trials.- 5. Practical Subgroup Identification Strategies in Late-stage Clinical Trials.- 6. Exploratory Subgroup Identification for Biopharmaceutical Development.- 7. Logical Inference on Treatment Efficacy When Subgroup Exists.- 8. The GUIDE Approach to Subgroup Identification and Inference.- 9. Use of the VG (Virtual Twins Combined with GUIDE) Method in the Development of Precision Medicines.- 10. Subgroups Identification for Tailored Therapies: a System of Methods, a Framework for Consistent Methodology Evaluation, and an Integrated Learn-and-confirm Approach.- 11. Developing and Validating Predictive Classifiers in Randomized Clinical Trials.- 12. Issues Related to Subgroup Analysis.- 13. Subgroup Analysis with Partial Linear Model.- 14. Subgroup Analysis in the 21st Century.- 15. Power of Statistical Tests for Subgroup Analysis in Meta-Analysis.- 16. Heterogeneity and Subgroup Analysis in Network Meta-Analysis.
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource (400 pages)
• Subjects: Statistics; Statistics ; Biostatistics; Pharmaceutical technology; Science -- Life Sciences -- General; Medical -- Pharmacy; Life sciences: general issues; Pharmaceutical technology; Medical -- Biostatistics; Probability & statistics
• Languages: English
• ISBNs: 9783030401054
• Related ISBNs: 9783030401047
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.