HSF1 and molecular chaperones in biology and cancer. (2020)
- Record Type:
- Book
- Title:
- HSF1 and molecular chaperones in biology and cancer. (2020)
- Main Title:
- HSF1 and molecular chaperones in biology and cancer
- Further Information:
- Note: Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval, editors.
- Editors:
- Mendillo, Marc Laurence
Pincus, David
Scherz-Shouval, Ruth - Contents:
- Intro -- Preface: Dedication to Susan Lindquist -- Contents -- Part I: Structure -- 1: Structural and Biochemical Properties of Hsp40/Hsp70 Chaperone System -- 1.1 Hsp70 Chaperone System -- 1.1.1 Hsp70 Domain Structure and Functional Cycle -- 1.1.2 Substrate Recognition and Remodeling by the Hsp70 Chaperones -- 1.2 Regulation of Hsp70 Function by Co-chaperones -- 1.2.1 J-Domain Proteins -- 1.2.2 Nucleotide Exchange Factors -- 1.2.2.1 Nucleotide Cycle Regulation Beyond JDPs and NEFs -- 1.3 Hsp70s Interaction with Other Cellular Chaperone Systems 1.3.1 Hsp70 Chaperones in Protein Disaggregation -- 1.4 Conclusion and Perspectives -- References -- 2: The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation -- 2.1 Introduction -- 2.2 The Structure of CCT -- 2.3 CCT Substrates and Specificity -- 2.4 Conformational Changes and Nucleotide Hydrolysis -- 2.5 CCT and Cancer -- 2.6 CCT as Key Regulator of Cell Cycle -- 2.7 Is CCT a Possible Antiproliferation Target? -- References -- 3: Regulation of Hsf1 and the Heat Shock Response -- 3.1 Introduction: The HSR in Health and Disease 3.2 Defining the Transcriptional Response to Heat Shock -- 3.3 What Activates the HSR? -- 3.4 Hsp70 and Hsf1 Constitute a Negative Feedback Loop That Controls the HSR -- 3.5 Hsp90 Negatively Regulates Hsf1 Orthogonally to Hsp70 -- 3.6 Phosphorylation Is Dispensable for Hsf1 Activity During Heat Shock -- 3.7 Coordination of the HSR Across Tissues -- 3.8 Conclusion -- References -- Part II: FunctionIntro -- Preface: Dedication to Susan Lindquist -- Contents -- Part I: Structure -- 1: Structural and Biochemical Properties of Hsp40/Hsp70 Chaperone System -- 1.1 Hsp70 Chaperone System -- 1.1.1 Hsp70 Domain Structure and Functional Cycle -- 1.1.2 Substrate Recognition and Remodeling by the Hsp70 Chaperones -- 1.2 Regulation of Hsp70 Function by Co-chaperones -- 1.2.1 J-Domain Proteins -- 1.2.2 Nucleotide Exchange Factors -- 1.2.2.1 Nucleotide Cycle Regulation Beyond JDPs and NEFs -- 1.3 Hsp70s Interaction with Other Cellular Chaperone Systems 1.3.1 Hsp70 Chaperones in Protein Disaggregation -- 1.4 Conclusion and Perspectives -- References -- 2: The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation -- 2.1 Introduction -- 2.2 The Structure of CCT -- 2.3 CCT Substrates and Specificity -- 2.4 Conformational Changes and Nucleotide Hydrolysis -- 2.5 CCT and Cancer -- 2.6 CCT as Key Regulator of Cell Cycle -- 2.7 Is CCT a Possible Antiproliferation Target? -- References -- 3: Regulation of Hsf1 and the Heat Shock Response -- 3.1 Introduction: The HSR in Health and Disease 3.2 Defining the Transcriptional Response to Heat Shock -- 3.3 What Activates the HSR? -- 3.4 Hsp70 and Hsf1 Constitute a Negative Feedback Loop That Controls the HSR -- 3.5 Hsp90 Negatively Regulates Hsf1 Orthogonally to Hsp70 -- 3.6 Phosphorylation Is Dispensable for Hsf1 Activity During Heat Shock -- 3.7 Coordination of the HSR Across Tissues -- 3.8 Conclusion -- References -- Part II: Function -- 4: Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease -- 4.1 Introduction 5: The Multifaceted Role of HSF1 in Tumorigenesis -- 5.1 Introduction -- 5.2 HSF1 Structure and Function -- 5.2.1 HSF1 Regulation by Post Translational Modification -- 5.3 HSF1 in Carcinogenesis -- 5.4 How Is HSF1 Activated in Cancer? -- 5.5 How Does HSF1 Support the Malignant State in Cancer? -- 5.5.1 HSF1 Regulation of Cancer Cell Proteostasis -- 5.5.2 HSF1 Regulation of mRNA Processing and Protein Synthesis -- 5.5.3 HSF1 Regulation of DNA Repair -- 5.5.4 HSF1 Regulation of Energy Metabolism -- 5.5.5 HSF1 Regulation of Cell Motility, Migration and Adhesion … (more)
- Publisher Details:
- Cham, Switzerland : Springer
- Publication Date:
- 2020
- Extent:
- 1 online resource (viii, 182 pages), illustrations (some color)
- Subjects:
- 572/.633
Molecular chaperones
Molecular chaperones
Electronic books
Electronic books - Languages:
- English
- ISBNs:
- 9783030402044
3030402045 - Related ISBNs:
- 9783030402037
- Notes:
- Note: Online resource; title from PDF title page (SpringerLink, viewed May 1, 2020).
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.507250
- Ingest File:
- 03_083.xml