Proteostasis and disease from basic mechanisms to clinics /: from basic mechanisms to clinics. ([2020])

• Record Type: Book
• Further Information: Note: Rosa Barrio, James D. Sutherland, Manuel S. Rodriguez, editors.
• Other Names: Barrio, Rosa; Rodriguez, Manuel S; Sutherland, James D
• Contents: Intro -- Preface -- Acknowledgments -- Contents -- Part I: Cancer -- Chapter 1: Ubiquitin-Regulated Cell Proliferation and Cancer -- 1.1 Introduction to Cell Cycle Regulation -- 1.1.1 Regulation of CDK-Cyclin Activity by the UPS -- 1.1.2 SCF in Cell Cycle Control -- 1.1.3 SCF in DNA Damage -- 1.1.4 APC/C and the Regulation of Mitosis -- 1.2 Non-proteolytic Protein Ubiquitination in the Control of Cell Cycle Progression -- 1.2.1 Cell Signaling and Non-proteolytic Protein Ubiquitination in G1 -- 1.2.2 Non-proteolytic Protein Ubiquitination During G1/S to G2 Transition 2.4.1.1 Ubiquitin E1 Inhibitors -- 2.4.1.2 Nedd8 E1 Inhibitors -- 2.4.1.3 SUMO E1 Inhibitors -- 2.4.2 E2 Inhibitors -- 2.4.3 E3 Inhibitors -- 2.4.3.1 MDM2 Inhibitors -- 2.4.3.2 IAP Inhibitors -- 2.5 Conclusion -- References -- Chapter 3: The Proteasome System in Health and Disease -- 3.1 Introduction -- 3.2 20S Proteasomes: Structure and Regulation -- 3.2.1 Alternative Composition of the 20S Proteasome -- 3.2.2 Expression and Assembly of the 20S Proteasome -- 3.2.3 Activation of the 20S Proteasome -- 3.2.4 Posttranslational Modifications (PTMs) -- 3.2.5 Localization --3.4 Proteasomes in Diseased States.
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Extent: 1 online resource (350 p.)
• Subjects: 572/.6; Proteomics; Proteins -- Metabolism; Ubiquitin; Diseases -- Molecular aspects; Proteins; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030382667; 3030382664
• Related ISBNs: 9783030382650; 3030382656
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.